Sox6, jack of all trades: a versatile regulatory protein in vertebrate development.
Sox6, jack of all trades: a versatile regulatory protein in vertebrate development.
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DOI：
10.1002/dvdy.22639
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发表时间：
2011-06
影响因子：
2.5
通讯作者：
Hagiwara, Nobuko
中科院分区：
文献类型：
--
作者：
Hagiwara, Nobuko
我们的基因组中编码了大约两万个基因，其中十分之一被认为是转录因子。考虑到发育过程中产生的细胞类型的复杂性和多样性，许多转录因子可能发挥多种作用。揭示Sox 6在脊椎动物发育中的多功能作用有助于了解生物体如何有效地利用有限的转录因子资源。Sox 6基因本身的结构可能决定了其功能的多样性。首先，Sox 6不包含已知的调控结构域;相反，它利用各种辅因子。其次，Sox 6有一个很长的3′-UTR，包含多个microRNA靶标，因此其蛋白质水平可以通过细胞类型特异性microRNA进行适当调节。仅仅结合这两个特性就使得Sox 6非常通用。迄今为止，Sox 6已被报道调节中胚层、外胚层和内胚层起源的组织的分化，使得Sox 6成为真正多方面的转录因子。
Approximately twenty thousand genes are encoded in our genome, one tenth of which are thought to be transcription factors. Considering the complexity and variety of cell types generated during development, many transcription factors likely play multiple roles. Uncovering the versatile roles of Sox6 in vertebrate development sheds some light on how an organism efficiently utilizes the limited resources of transcription factors. The structure of the Sox6 gene itself may dictate its functional versatility. First, Sox6 contains no known regulatory domains; instead, it utilizes various cofactors. Second, Sox6 has a long 3′-UTR that contains multiple microRNA targets, thus its protein level is duly adjusted by cell type-specific microRNAs. Just combining these two characteristics alone makes Sox6 extremely versatile. To date, Sox6 has been reported to regulate differentiation of tissues of mesoderm, ectoderm, and endoderm origins, making Sox6 a truly multifaceted transcription factor.
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