AUTOIMMUNE THROMBOCYTOPENIC PURPURA IN HOMOSEXUAL MEN
AUTOIMMUNE THROMBOCYTOPENIC PURPURA IN HOMOSEXUAL MEN
复制标题
DOI：
10.7326/0003-4819-96-6-714
复制
发表时间：
1982-01-01
影响因子：
39.2
通讯作者：
KARPATKIN, S
中科院分区：
文献类型：
--
作者：
MORRIS, L;DISTENFELD, A;KARPATKIN, S
自1980年11月以来，共诊断出11例男性同性恋者的严重自身免疫性血小板减少性紫癜，其平均血小板计数（. ±. 16，000+。3000/mm3。所有患者都曾与多个性伴侣发生过性行为，并接触过多种病毒和药物。在此期间，还诊断出20例异性恋者的经典自身免疫性血小板减少性紫癜，正常男女比例为3：1。9例同性恋者中8例血小板IgG升高，与10例血象正常的同性恋者中8例血小板IgG正常值比较，差异有显著性（P < 0.01）。所有患者均对类固醇有中度或完全反应。3例行脾切除术的患者反应良好。与健康对照组相比，5例患者中有4例的辅助/抑制T细胞比率降低（P < 0.001）。循环免疫复合物和总γ与对照组比较，同性恋者血清球蛋白水平升高，淋巴细胞水平相对降低（P < 0.05）。一些性活跃的同性恋男性似乎有针对血小板的免疫调节紊乱的发病率增加。
Since Nov. 1980 11 cases of severe autoimmune thrombocytopenic purpura in homosexual men were diagnosed; their mean platelet count (.+-. SE) was 16,000 .+-. 3000/mm3. All patients had been sexually active wiht multiple partners and exposed to numerous viruses and drugs. During this period, 20 cases of classic autoimmune thrombocytopenic purpura in heterosexual persons were also diagnosed, with a normal women to men ratio of 3:1. Eight of 9 homosexual patients had elevated platelet IgG compared with normal values in 8 of 10 homosexual control subjects having normal hemograms (P < 0.01). All responded moderately or completely to steroids. The 3 patients who had splenectomy had excellent responses. Four of 5 patients had a decreased helper/suppressor T cell ratio compared to healthy controls (P < 0.001). Circulating immune complexes and total .gamma. globulin levels were elevated and lymphocytes relatively decreased in homosexual patients compared with homosexual controls (P < 0.05). Some sexually-active homosexual men seem to have an increased incidence of an immune regulation disorder directed against platelets.