Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?
Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?
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DOI：
10.1016/s0304-3959(99)00111-6
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发表时间：
1999-11-01
期刊：
影响因子：
7.4
通讯作者：
Singh, L
中科院分区：
文献类型：
--
作者：
Field, MJ;Bramwell, S;Singh, L
在本研究中，坐骨神经慢性收缩损伤（CCI模型）或L5和L6脊神经紧密结扎（Chung模型）均产生大鼠机械异痛的动态和静态成分。这两种反应分别是通过用棉毛轻轻抚摸后爪或用von Prey毛发施加压力来检测的。脊髓神经结扎的动物比CCI的动物产生这两种反应的速度更快。吗啡（1- 3mg /kg, s.c）剂量依赖性阻断静态异痛感，但不阻断动态异痛感。相比之下，普瑞巴林（以前的s -异丁基gaba和CI-1008）剂量依赖性（3-30 mg/kg, p.o）阻断了这两种类型的异常性疼痛。在CCI动物中，每隔1小时向同侧足跖表面注射两次辣椒素（100 μ g/50 μ l），可阻断热痛觉过敏的维持，而不影响静态或动态异常性疼痛。在相同的动物中再给同样剂量的辣椒素，在不影响动态反应的情况下，阻止了静态异常性疼痛的维持。这些数据表明，热痛觉过敏、静态和动态异常性痛觉分别由C-、A delta-和A β /辣椒素不敏感的A delta初级感觉神经元发出信号。这表明普瑞巴林具有比吗啡更好的抗异动性，可能代表了一类新的治疗神经性疼痛的药物。(C) 1999年国际疼痛研究协会。Elsevier Science B.V.出版
In the present study, chronic constrictive injury (CCI model) of the sciatic nerve or tight ligation of L5 and L6 spinal nerves (Chung model) produced both dynamic and static components of mechanical allodynia in rats. The two responses were detected, respectively, by lightly stroking the hind paw with cotton wool or application of pressure using von Prey hairs. Animals with spinal nerve ligation developed both types of responses at a faster rate compared to animals with the CCI. Morphine (1-3 mg/kg, s.c.) dose-dependently blocked static but not dynamic allodynia. In contrast, pregabalin (previously S-isobutylgaba and CI-1008) dose-dependently (3-30 mg/kg, p.o.) blocked both types of allodynia. In CCI animals, two administrations of capsaicin (100 mu g/50 mu l) into the plantar surface of the ipsilateral paw at 1-h intervals blocked the maintenance of thermal hyperalgesia without affecting either static or dynamic allodynia. The similar administration of a further two doses of capsaicin into the same animals blocked the maintenance of static allodynia without affecting the dynamic response. These data indicate that thermal hyperalgesia, static and dynamic allodynia are respectively signalled by C-, A delta- and A beta/capsaicin insensitive A delta-primary sensory neurones. It is suggested that pregabalin possesses a superior antiallodynic profile than morphine and may represent a novel class of therapeutic agents for the treatment of neuropathic pain. (C) 1999 International Association for the Study of Pain. Published by Elsevier Science B.V.