Regiochemical switching of Mitsunobu cyclisation mode of vicinal diamines with pendant hydroxyl group.
Regiochemical switching of Mitsunobu cyclisation mode of vicinal diamines with pendant hydroxyl group.
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带有侧羟基的邻位二胺的 Mitsunobu 环化模式的区域化学转换。
DOI：
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发表时间：
2007
影响因子：
3.2
通讯作者：
Helen A. Chapman
中科院分区：
文献类型：
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作者：
James C. Anderson;Helen A. Chapman
在 Mitsunobu 条件下，源自硝基曼尼希反应的含有甲苯磺酰酰胺和仲胺的环境 1,2-二胺可以通过甲苯磺酰酰胺区域选择性环化到侧伯羟基上，得到哌嗪（60-75% 产率）或 1,4-二氮杂环庚烷（71% 产率）环系统。对于某些底物，添加 Et(3)N.HCl 会促进通过仲胺进行区域选择性环化，形成氮丙啶环系统。
Ambident 1,2-diamines derived from the nitro-Mannich reaction containing both a tosyl amide and a secondary amine could be regioselectively cyclised through the tosyl amide onto a pendant primary hydroxyl group to give piperazine (60-75% yields) or 1,4-diazepane (71% yield) ring systems under Mitsunobu conditions. For some substrates addition of Et(3)N.HCl encouraged regioselective cyclisation through the secondary amine leading to aziridine ring systems.
影响因子：
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作者：
T. Yoon;E. Jacobsen
通讯作者：
T. Yoon;E. Jacobsen