FTO polymorphisms in oceanic populations
FTO polymorphisms in oceanic populations
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DOI：
10.1007/s10038-007-0198-2
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发表时间：
2007-12-01
影响因子：
3.5
通讯作者：
Ohtsuka, Ryutaro
中科院分区：
文献类型：
--
作者：
Ohashi, Jun;Naka, Izumi;Ohtsuka, Ryutaro
有人认为，尼尔的“节俭基因型”模型可能解释了一些大洋洲种群的高体重，这可能是在现代出现的。在欧洲人群中，最近发现脂肪量和肥胖（FTO相关）中的常见变异（rs 1421085-C、rs 17817449-G和rs 9939609-A）与体重指数（BMI）或肥胖相关。在这项研究中，我们调查了这些变异在六个大洋洲人群（美拉尼西亚人，波利尼西亚人和波利尼西亚人）中的人群频率，并测试了与BMI的相关性。与欧洲人群不同，大洋洲人群的FTO多态性和BMI之间没有显着关联。这些变异体处于强连锁不平衡状态。6个大洋性种群的种群频率在4.2%~ 30.3%之间，与东南亚和东亚种群的频率相近。我们对FTO多态性的研究没有产生支持大洋种群节俭基因型假说的证据。
It has been suggested that Neel's "thrifty genotype" model may account for high body weights in some Oceanic populations, which presumably arose in modern times. In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity. In this study, we investigated the population frequencies of these variants in six Oceanic populations (Melanesians, Micronesians, and Polynesians) and tested for an association with BMI. Unlike European populations, the Oceanic populations displayed no significant association between the FTO polymorphisms and BMI. These variants were in strong linkage disequilibrium. The population frequencies ranged between 4.2 and 30.3% in the six Oceanic populations, and were similar to those in southeast and east Asian populations. Our study of the FTO polymorphisms has generated no evidence to support the thrifty genotype hypothesis for Oceanic populations.