At the heart of the statin benefit.
At the heart of the statin benefit.
复制标题
他汀类药物益处的核心。
DOI：
10.1016/j.jacc.2005.07.032
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发表时间：
2005
影响因子：
24
通讯作者：
J. Larosa
中科院分区：
文献类型：
--
作者：
J. Larosa
Almost since they were first introduced, statin drugs have been recognized to have effects beyond their potent low-density lipoprotein (LDL)-lowering abilities. These “pleitropic” effects include anti-inflammatory, vascular, and immune-altering properties (1). Their existence has led to suggestions that statins might be useful in other diseases, ranging from dementia to autoimmune disorders. They have been invoked to explain the unexpectedly early reduction in coronary events in statin clinical trials, contrary to the later appearance of benefits in non-statin LDL-lowering trials. They also have been implicated in the strong benefit of statin therapy in preventing atherothrombotic strokes, even though cholesterol levels are, at best, weak predictors of stroke in observational studies. Evidence of the prominent role of inflammation in atherogenesis has grown apace with the evidence for the anti-inflammatory effects of statins. Perhaps as a result, this property has received the most attention as one of potential clinical significance.
