Antineoplastic agents.: 386.: Isolation of sesterstatins 1-3 from the marine sponge Hyrtios erecta
Antineoplastic agents.: 386.: Isolation of sesterstatins 1-3 from the marine sponge Hyrtios erecta
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DOI：
10.1021/np970203
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发表时间：
1998-01-01
影响因子：
5.1
通讯作者：
Pettit, RK
中科院分区：
文献类型：
--
作者：
Pettit, GR;Cichacz, ZA;Pettit, RK
马尔代夫共和国的黑色海绵Hyrtios erecta被发现含有三种癌细胞系抑制性五环酯萜，称为酯抑素1-3（2-4）。其中一种酯萜，酯抑素2，能特异性抑制革兰氏阳性机会性金黄色葡萄球菌。所有三种P-388淋巴细胞白血病活性（ED50 0.46至4.3 μ g/mL）酯他汀类药物均以痕量（3.0 × 10（-7）至5.4 × 10(-7)%产率）获得，并代表了更常见的scalarin型多孔菌酯萜的结构变化。利用高场（500 MHz）二维核磁共振技术和HRMS结果对结构进行了分析。
The Republic of Maldives' black marine sponge Hyrtios erecta has been found to contain three cancer cell-line inhibitory pentacyclic sesterterpenes designated sesterstatins 1-3 (2-4). One of the sesterterpenes, sesterstatin 2, specifically inhibited the Gram-positive opportunist Staphylococcus aureus. All three of the P-388 lymphocytic-leukemia-active (ED50 0.46 to 4.3 mu g/mL) sesterstatins were obtained in trace quantities (3.0 x 10(-7) to 5.4 x 10(-7)% yields) and represent structural variations on the more usual scalarin-type porifera sesterterpenes. The structures were elucidated by highfield (500 MHz) 2D NMR techniques augmented by HRMS results.