Daily walking reduces visceral adipose tissue areas and improves insulin resistance in Japanese obese subjects
Daily walking reduces visceral adipose tissue areas and improves insulin resistance in Japanese obese subjects
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DOI：
10.1016/s0168-8227(02)00129-8
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发表时间：
2002-11-01
影响因子：
5.1
通讯作者：
Fujii, M
中科院分区：
文献类型：
--
作者：
Miyatake, N;Nishikawa, H;Fujii, M
目的：众所周知，腹部脂肪堆积是动脉粥样硬化的危险因素之一。虽然运动通常被用于减轻体重，但低强度运动对减少腹部内脏脂肪组织的功效仍有待研究。研究设计和方法：31名年龄在32岁至59岁之间的肥胖日本男性（体重指数（BMI）大于或等于25）参加了一项为期1年的随访研究，并指示他们适度增加日常活动并记录他们的日常步行。记录运动处方前后的身体成分、血压、体能即有氧运动水平、肌肉力量和柔韧性。采用稳态模型HOMA指数评价胰岛素抵抗。结果：HOMA指数、体成分、血压、甘油三酯、高密度脂蛋白胆固醇等指标均明显改善。有氧运动水平、腿部力量、负重指数（腿部力量/体重）和每日步数均显著增加。多元逐步回归分析显示，Δ内脏脂肪面积是影响Δ HOMA指数的主要因素。（Δ HOMA指数= -0.386+0.016 Δ内脏脂肪组织面积，r（2）= 0.267，P < 0.01）。运动量、卡路里摄入量与Δ内脏脂肪组织面积无显著相关性，而Δ内脏脂肪组织面积与Δ每天步行量有显著相关性（Δ内脏脂肪组织面积= -21.363-0.004 Δ每天步行量，r（2）= 0.184，P = 0.0326）。结论：总之，腹内内脏脂肪组织与胰岛素抵抗和日常步行密切相关，而与肥胖日本男性内脏脂肪组织减少相关的运动能力改善无关。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Objective: It is known that the accumulation of abdominal fat is one of the risk factors for atherosclerosis. Although exercise is commonly prescribed to reduce body weight, the efficacy of low intensity exercise for the reduction of abdominal visceral adipose tissue remains to be investigated. Research design and methods: Thirty one obese Japanese males (body mass index (BMI) greater than or equal to 25) ranging in age from 32 to 59, participated in a 1-year follow up study and they were instructed to have a modest increase in daily activity and record their daily walking. Before and after exercise prescription, body composition, blood pressure, physical fitness i.e. aerobic exercise level, muscle strength and flexibility were recorded. Insulin resistance was evaluated using a homeostasis model assessment, the HOMA index. Results: HOMA index, parameters of body composition, blood pressure, triglyceride and HDL cholesterol were significantly improved. The aerobic exercise level, leg strength, weight-bearing index (leg strength/body weight) and the steps taken per day were significantly increased. By stepwise multiple regression analysis, Deltavisceral adipose tissue area was the major determinant for DeltaHOMA index. (DeltaHOMA index = -0.386+0.016 Deltavisceral adipose tissue area, r(2) = 0.267, P < 0.01). Exercise capacity and calorie intake were not significantly related to Deltavisceral adipose tissue area, while Deltasteps per day was significantly correlated with Deltavisceral adipose tissue area (Deltavisceral adipose tissue area = -21.363-0.004Delta steps per day, r(2) = 0.184, P = 0.0326). Conclusions: Taken together, intra-abdominal visceral adipose tissue is critically involved in insulin resistance and daily walking rather than improvement of exercise capacity correlated with the reduction of visceral adipose tissue in obese Japanese males. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.