Concomitant endocrine and immune alterations during alcohol intoxication and acute withdrawal in alcohol-dependent subjects
Concomitant endocrine and immune alterations during alcohol intoxication and acute withdrawal in alcohol-dependent subjects
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DOI：
10.1159/000054955
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发表时间：
2002-01-01
影响因子：
3.2
通讯作者：
Exton, MS
中科院分区：
文献类型：
--
作者：
Kutscher, S;Heise, DJ;Exton, MS
虽然酒精中毒和戒断都被证明会产生显著的内分泌改变，但没有关于急性戒断对免疫功能影响的数据。因此，本研究探讨酒精中毒和急性戒断对血浆皮质醇，催乳素和儿茶酚胺，血白细胞亚群分布在酒精依赖的受试者的影响。9名因酒精依赖而被大学诊所收治的男性酗酒者和9名年龄匹配的对照组参与了这项研究。在第0天（慢性酒精中毒）上午10：30、急性酒精戒断期间（第1天）的同一时间和急性戒断消退后（第7天），从酒精依赖受试者中抽取血液。在相应的时间点从年龄和性别匹配的健康对照受试者中抽取血液。然后分析血浆中的激素浓度，并通过流式细胞术检查血液中的白细胞亚群。酒精依赖患者在中毒和戒断过程中血浆皮质醇显著升高，在急性戒断症状缓解后降至对照水平。在中毒过程中也观察到血浆催乳素和儿茶酚胺的小幅升高。此外，在所有时间点，与健康对照组相比，酒精依赖受试者的CD 4（+）和CD 8（+）T细胞和自然杀伤细胞绝对数量减少。相比之下，尽管酒精依赖患者在中毒期间单核细胞数量较低，但急性酒精戒断增加了患者的单核细胞数量。因此，酒精依赖产生血液中白细胞亚群的总体抑制。然而，急性酒精戒断的解决与血浆皮质醇恢复到对照水平，以及外周血单核细胞数量的伴随增加有关。版权所有（C）2002 S. Karger AG，巴塞尔。
Although both alcohol intoxication and withdrawal have been demonstrated to produce significant endocrine alterations, no data exist on the effects of acute withdrawal on immune functions. Therefore, the current study investigated the effect of alcohol intoxication and acute withdrawal on plasma cortisol, prolactin and catecholamines, and blood leukocyte subset distribution in alcohol-dependent subjects. Nine male alcoholics admitted to the university clinic for alcohol dependence and 9 age-matched controls participated in the study. Blood was drawn from the alcohol-dependent subjects at 10:30 a.m. on day 0 (chronic alcohol intoxication), at the same time during acute alcohol withdrawal (day 1) and following the resolution of acute withdrawal (day 7). Blood was drawn from age- and gender-matched healthy control subjects at the corresponding time points. Plasma was then analyzed for hormone concentrations and blood examined for leukocyte subsets by flow cytometry. Alcohol-dependent patients displayed significantly elevated plasma cortisol during intoxication and withdrawal, which decreased to control levels following resolution of acute withdrawal. Small elevations of plasma prolactin and catecholamines were also observed during intoxication. Furthermore, alcohol-dependent subjects showed reduced absolute numbers of CD4(+) and CD8(+) T cells and natural killer cells compared with healthy controls across all time points. In contrast, although monocyte numbers were lower in alcohol-dependent patients during intoxication, acute alcohol withdrawal increased the number of monocytes in patients. Thus, alcohol dependence produces a general suppression of leukocyte subset populations in blood. However, resolution of acute alcohol withdrawal is associated with a return of plasma cortisol to control levels, and a concomitant increase in peripheral blood monocyte numbers. Copyright (C) 2002 S. Karger AG, Basel.