Numerical study of dynamic zigzag patterns in migrating epithelial tissue
Numerical study of dynamic zigzag patterns in migrating epithelial tissue
复制标题
迁移上皮组织动态之字形模式的数值研究
DOI：
10.1007/s11433-021-1778-y
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Yu
中科院分区：
文献类型：
--
作者：
L. Cai;Wenjie Ji;Jie Luo;Qun;Yu
集体细胞迁移在胚胎发育、转移和伤口愈合中起着至关重要的作用。然而，据我们所知，细胞运动和变形之间的协调如何影响上皮细胞的集体运动还没有完全了解。在这项工作中，我们提出了一个修改后的自推进Voronoi模型上皮细胞迁移纳入细胞的自推进和细胞伸长的极化之间的耦合。在高耦合强度下，我们观察到由高度对准的细胞形成的向后行进带结构的出现，其可以通过细胞伸长或形状各向异性来调节。增加细胞形状的各向异性，我们发现，大带分裂成多个小的微带。后者本质上形成一个动态的锯齿形图案，其中条带的偏振方向与迁移方向之间的角度在π/4和-π/4之间交替切换，因为细胞被迫优先向前移动。我们还分析了在细胞单层的向错，力分布附近的域边界和形状排列的上皮单层在形成这种动态模式。目前的研究结果可能会进一步加深我们对生命系统中条纹图案形成的理解，并激发潜在的细胞分选设计。
Collective cell migration plays a crucial role in embryonic development, metastasis, and wound healing. Nevertheless, to the best of our knowledge, how the coordination between the cell motility and deformations affects the collective motion of epithelial cells is not fully understood. In this work, we propose a modified self-propelled Voronoi model for epithelial cell migration incorporating the coupling between the self-propulsion of cells and the polarization of the cell elongation. At a high coupling strength, we observe the emergence of backward traveling band structures formed by highly aligned cells, which can be regulated by cell elongations or shape anisotropy. Increasing the cell shape anisotropy, we find that large bands split into multiple small microbands. The latter essentially forms a dynamic zigzag pattern, in which the angle between the polarization direction of the bands and the migration direction switches alternatively between π/4 and −π/4 because the cells are forced to move preferentially in the anterior direction. We also analyzed the disclinations in the cell monolayer, force distribution near the domain boundaries and the shape alignment of the epithelial monolayer during the formation of this dynamic pattern. The present findings may further our understanding of stripe pattern formations in living systems and inspire potential designs for cell sorting.
影响因子：
5.3
作者：
Shijie He;Yoav Green;N. Saeidi;Xiaojun Li;J. Fredberg;B. Ji;L. Pismen
通讯作者：
Shijie He;Yoav Green;N. Saeidi;Xiaojun Li;J. Fredberg;B. Ji;L. Pismen
影响因子：
64.8
作者：
Mongera A;Rowghanian P;Gustafson HJ;Shelton E;Kealhofer DA;Carn EK;Serwane F;Lucio AA;Giammona J;Campàs O
通讯作者：
Campàs O