Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines
Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines
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DOI：
10.1021/acs.oprd.7b00229
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发表时间：
2017-10-01
影响因子：
3.4
通讯作者：
Ley, Steven V.
中科院分区：
文献类型：
--
作者：
Battilocchio, Claudio;Bosica, Francesco;Ley, Steven V.
我们报道了制备二溴甲醛肟 (DBFO) 作为前体来生成 3-溴异恶唑啉的多步连续工艺。我们还报告了工艺改进，可提供超过 620 mmol h(-1) 的 DBFO 生产率。
We report the multistep continuous process for the preparation of dibromoformaldoxime (DBFO) as a precursor to generate 3-bromoisoxazolines. We also report process improvements that afford a productivity of over 620 mmol h(-1) of DBFO.