Genetic research participation in a young adult community sample.
Genetic research participation in a young adult community sample.
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参与年轻成人社区样本的基因研究。
DOI：
10.1007/s12687-014-0191-3
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发表时间：
2014
影响因子：
1.9
通讯作者：
Ialongo,Nicholas
中科院分区：
文献类型：
--
作者：
Storr,CarlaL;Or,Flora;Eaton,WilliamW;Ialongo,Nicholas
与大型国家赞助的健康计划或生物库相反，人们对从参与以学术社区为基础的精神健康和物质使用流行病学研究的年轻人中收集遗传样本知之甚少，特别是大量少数民族参与者的样本。这项研究描述了我们在一组年轻人（平均年龄29岁，75%非裔美国人，58%女性）的纵向研究中建立遗传臂的经验。总的来说，在最近一波的采访中，75%的人捐赠了DNA样本（31.6%的血液和68.4%的唾液），超过90%的人同意储存和分享。目前吸烟者比不吸烟者更有可能捐献样本（调整后的比值比（aOR）= 1.59，95%置信区间（CI）= 1.14，2.22）。对于那些曾经吸食大麻和经常喝酒的人来说，获得唾液样本的几率增加了，但对于受教育程度较低和有吸毒史的参与者来说，这种几率降低了。少数民族（aOR = 0.37，95% CI = 0.18，0.75;p= 0.006）和大麻使用者（aOR = 0.46，95% CI = 0.27，0.77）同意与其他研究人员分享他们的样本。研究结果还表明，有许多研究参数是重要的生物收集工作的规划。与受试者建立密切的关系和信任，最大限度地减少受访者获取生物样本的负担，提供提供血液或唾液的选择，并提供激励措施，将增加获取样本的可能性，重要的是，增加未来存储和共享样本的机会。
Opposed to large nationally sponsored health initiatives or biobanks, little is known about gathering genetic samples from young adults participating in academic community-based epidemiologic studies of mental health and substance use, especially samples with a large number of minority participants. This study describes our experience of establishing a genetic arm within a longitudinal study of a cohort of young adults (mean age 29, 75 % African American, 58 % female). In total, 75 % of those interviewed in the most recent wave donated a DNA sample (31.6 % blood and 68.4 % saliva) and over 90 % provided consent for storage and sharing. Current smokers were more likely to donate a sample than nonsmokers (adjusted odds ratio (aOR) = 1.59, 95 % confidence interval (CI) = 1.14, 2.22). The odds of obtaining a saliva sample were increased for those who were former cannabis smokers and who drank more regularly, but decreased among participants with less education and a history with drug use. Fewer minorities (aOR = 0.37, 95 % CI = 0.18, 0.75;p= 0.006) and cannabis users (aOR = 0.46, 95 % CI = 0.27, 0.77) consented to sharing their sample with other investigators. Findings also illustrate there are many study parameters that are important in planning biologic collection efforts. Building strong rapport and trust with subjects, minimizing the burden involved by the respondent to obtain a biological sample, offering a choice to provide blood or saliva, and offering an incentive will increase the likelihood of obtaining a sample and, importantly, increase the opportunity to store and share the sample for the future.