Reduction of hypoglycaemia, lifestyle modifications and psychological distress during lockdown following SARS-CoV-2 outbreak in type 1 diabetes
Reduction of hypoglycaemia, lifestyle modifications and psychological distress during lockdown following SARS-CoV-2 outbreak in type 1 diabetes
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DOI：
10.1002/dmrr.3404
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发表时间：
2020-10-05
影响因子：
8
通讯作者：
Laviola, Luigi
中科院分区：
文献类型：
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作者：
Caruso, Irene;Di Molfetta, Sergio;Laviola, Luigi
目的 在严重急性呼吸综合征冠状病毒 2 爆发后，在封锁期间使用快速血糖监测 (FGM) 来评估 1 型糖尿病 (T1D) 患者的血糖指标变化及其与心理困扰和生活方式变化的关系。材料和方法 这是一项单中心、观察性、回顾性研究，招募了 2020 年 4 月在意大利巴里综合医院内分泌科进行远程访视的 1 型糖尿病患者。在半定量的基础上评估了与封锁相关的体力活动水平和饮食习惯的变化。总体健康状况的变化通过一般健康问卷 12 个项目和二元评分系统进行评估。从 Libreview 平台获取 2020 年 2 月前 2 周 (T0) 和电话就诊前最后 2 周 (T1) 的血糖指标。结果 在接受资格评估的 84 名患者中，48 名患者拥有足够的 FGM 数据可纳入分析。 FGM 数据分析显示变异系数、低血糖事件数量和低于范围的时间显着减少，而范围内时间、高于范围的时间、平均传感器血糖和血糖管理指标没有变化。此外，糖果消费频率与封锁期间低血糖事件的发生呈负相关。结论 与封锁相关的生活方式改变，尽管不健康，但可能会导致 1 型糖尿病患者中由 FGM 衍生的低血糖和血糖变异性指标减少。
Aims To assess changes in glucose metrics and their association with psychological distress and lifestyle changes in patients with type 1 diabetes (T1D) using flash glucose monitoring (FGM) during lockdown following severe acute respiratory syndrome coronavirus 2 outbreak. Materials and methods Single-centre, observational, retrospective study enrolling T1D patients who attended a remote visit on April 2020 at the Endocrinology division of the University Hospital Policlinico Consorziale, Bari, Italy. Lockdown-related changes in physical activity level and dietary habits were assessed on a semi-quantitative basis. Changes in general well-being were assessed by the General Health Questionnaire-12 items with a binary scoring system. Glucose metrics were obtained from the Libreview platform for the first 2 weeks of February 2020 (T0) and the last 2 weeks before the phone visit (T1). Results Out of 84 patients assessed for eligibility, 48 had sufficient FGM data to be included in the analysis. FGM data analysis revealed significant reductions in coefficient of variation, number of hypoglycaemic events, and time below range, while no changes were found in time in range, time above range, mean sensor glucose, and glucose management indicator. Moreover, the frequency of sweets consumption was inversely related to the occurrence of hypoglycaemic events during lockdown. Conclusions Lockdown-related lifestyle changes, albeit unhealthy, may lead to reduction in FGM-derived measures of hypoglycaemia and glycaemic variability in patients with T1D.