Neuropsychological Performance and Mood States following Acute Interferon-β-1b Administration in Healthy Males
Neuropsychological Performance and Mood States following Acute Interferon-β-1b Administration in Healthy Males
复制标题
健康男性急性干扰素-β-1b 给药后的神经心理表现和情绪状态
作者：
M. Exton;Jan Baase;Volker Pithan;M. Goebel;V. Limmroth;M. Schedlowski
干扰素-β-1b（IFN-β-1b）已被证明可以降低复发缓解型多发性硬化（MS）患者的复发率和继发性进展型MS患者的疾病进展。虽然已知IFN-β-1b的急性给药会导致流感样症状，但已表明慢性药物治疗会导致情绪改变和焦虑发作，并继发于可能影响日常生活的神经心理学缺陷。然而，尚不清楚后者症状是否由急性IFN-β-1b给药引起。因此，我们在8名健康男性中检查了单次皮下注射IFN-β-1b的影响。在交叉设计中，每名受试者在8：00 h皮下注射800万IU IFN-β-1b或安慰剂（NaCl）。在基线、注射后4、8和24 h评估流感样症状（体温、心率、血压）、情绪状态（“情绪状态特征”、BFS）和神经心理学表现（轨迹标记测试、文字记忆测试、d2注意力测试）。IFN-β-1b增加体温、心率和疲劳。然而，急性IFN-β-1b注射没有损害任何神经心理学表现的参数。因此，尽管IFN-β-1b产生指示疾病行为的生理症状，但这些数据表明IFN-β-1b给药对急性给药后的认知能力没有影响。
Interferon-β-1b (IFN-β-1b) has been shown to reduce the relapse rate in patients with relapsing-remitting multiple sclerosis (MS) and disease progression in patients with secondary progressive MS. While acute administration of IFN-β-1b is known to cause flu-like symptoms, chronic medication has been suggested to cause mood alterations and anxiety attacks, and secondary to this neuropsychological deficits that may impair daily life. It is unknown, however, whether the latter symptoms are induced by acute IFN-β-1b administration. Therefore, we examined the impact of a single subcutaneous injection of IFN-β-1b in 8 healthy males. In a crossover design, each subject was injected subcutaneously with either 8 million IU IFN-β-1b or placebo (NaCl) at 8:00 h. Flu-like symptoms (body temperature, heart rate, blood pressure), mood status [‘profile of mood states’, Befindlichkeitsskala (BFS)] and neuropsychological performance (trail marking test, verbal memory test, d2 attention test) and were assessed at baseline, 4, 8 and 24 h after injection. IFN-β-1b increased body temperature, heart rate and fatigue. Nevertheless, acute IFN-β-1b injection did not impair any parameters of neuropsychological performance. Thus, although IFN-β-1b produces physiological symptoms indicative of sickness behavior, these data suggest that IFN-β-1b administration does not have an impact on the cognitive capacity following acute administration.
干扰素β-1a对复发性多发性硬化症的神经心理学影响。
影响因子：
11.2
作者：
Fischer,JS;Priore,RL;Jacobs,LD;Cookfair,DL;Rudick,RA;Herndon,RM;Richert,JR;Salazar,AM;Goodkin,DE;Granger,CV;Simon,JH;Grafman,JH;Lezak,MD;O'ReillyHovey,KM;Perkins,KK;Barilla-Clark,D;Schacter,M;Shucard,DW;
通讯作者：
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DOI：
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发表时间：
1995-07
期刊：
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影响因子：
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作者：
B. Kolb;I. Whishaw
通讯作者：
B. Kolb;I. Whishaw