Adherence of platelets to human endothelial cells infected by Rickettsia rickettsii.
Adherence of platelets to human endothelial cells infected by Rickettsia rickettsii.
复制标题
DOI：
10.1093/infdis/153.4.694
复制
发表时间：
1986-04
期刊：
影响因子：
--
通讯作者：
D. J. Silverman
中科院分区：
文献类型：
--
作者：
D. J. Silverman
立克次氏体是落基山斑疹热的病原体，由于小血管内皮细胞的广泛损伤而引起广泛的血管炎。对这些细胞的损伤可导致内皮衬里的剥脱和血栓形成的内皮下层的暴露。细胞表面的修饰，无论是通过轻微的创伤或作为改变细胞表面生物化学的结果，可以诱导变化，反映在增加血小板反应性。由于R.当立克次氏体进入内皮细胞时，检查了这种生物体感染引起血小板与内皮细胞表面反应性增加的可能性。感染红细胞的人脐静脉内皮细胞与血小板的粘附增加了4倍。这些研究表明，血小板粘附到立克次体感染的内皮细胞表面可以有助于在人类感染期间血液中循环血小板数量的减少。
Rickettsia rickettsii, the etiologic agent of Rocky Mountain spotted fever, causes widespread vasculitis due to extensive injury of endothelial cells lining small blood vessels. Injury to these cells can lead to denudation of the endothelial lining and exposure of the thrombogenic subendothelium. Modification of the cell surface, either through minor trauma or as a result of altered cell surface biochemistry, could induce changes reflected in increased platelet reactivity. Because membrane modification is likely when R. rickettsii enters endothelial cells, the possibility that infection by this organism caused increased reactivity of platelets with the endothelial cell surface was examined. A fourfold increase in adherence of platelets to cultured endothelial cells from the human umbilical vein infected by R. rickettsii compared with uninfected cells was found. These studies suggest that the adherence of platelets to the surface of Rickettsia-infected endothelial cells can contribute to reduction in the number of circulating platelets in blood during human infection.