Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.
Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.
复制标题
患有创伤后应激障碍的退伍军人的非噩梦般的痛苦觉醒：对哌唑嗪的反应。
DOI：
10.1002/jts.20351
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发表时间：
2008
影响因子：
3.3
通讯作者：
Raskind,MurrayA
中科院分区：
文献类型：
--
作者：
Thompson,CharlesE;Taylor,FletcherB;McFall,MilesE;Barnes,RobertF;Raskind,MurrayA
对22名患有创伤后应激障碍(PTSD)的退伍军人进行了创伤相关噩梦和非噩梦痛苦觉醒(NNDA)的评估，治疗前后使用α-1肾上腺素受体拮抗剂哌唑嗪，平均睡前剂量为9.6 mg/d。结合创伤相关噩梦的频率和强度维度的评级从3.6降至2.2，NNDA从5.2降至2.1，睡眠困难从7.2降至4.1每周。这些结果表明，脑肾上腺素能活动的增加可能与创伤相关噩梦和创伤后应激障碍的NNDA的病理生理学有关。
Twenty‐two veterans with posttraumatic stress disorder (PTSD) were assessed for trauma‐related nightmares and nonnightmare distressed awakenings (NNDA) before and after treatment with the alpha‐1 adrenoreceptor antagonist prazosin at an average bedtime dose of 9.6 mg/day. Ratings combining frequency and intensity dimensions of trauma‐related nightmares decreased from 3.6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain adrenergic activity may contribute to the pathophysiology of both trauma‐related nightmares and NNDA in PTSD.