Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers.
Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers.
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DOI：
10.2147/nss.s301113
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发表时间：
2021
影响因子：
3.4
通讯作者：
Pham LV
中科院分区：
文献类型：
--
作者：
Duan D;Gu C;Polotsky VY;Jun JC;Pham LV
饮食时间和睡眠习惯是影响代谢健康的重要可改变行为，但食物摄入和睡眠之间的关系仍然不完全清楚。观察数据表明，晚进食与睡眠质量受损有关。我们研究了常规晚餐（RD，睡前5小时）与晚晚餐（LD，睡前1小时）对健康志愿者睡眠结构的影响。这是一项在实验室环境中采用固定睡眠时间的RD与LD随机交叉研究的事后分析。在两次访视中的每一次，20名健康成年志愿者（10名女性）接受等热量餐，然后进行整夜多导睡眠描记。通过视觉睡眠分期和EEG频谱功率分析评估夜间睡眠结构，并比较RD和LD之间的差异。我们模拟了α，β，δ和θ波段的光谱功率的比例，作为晚餐时间，夜间时间的函数，以及它们与混合效应样条回归的相互作用。两次访视之间的常规睡眠阶段相似。LD导致δ功率初始增加2.5%，α和β功率组合倒数降低2.7%（p<0.0001）。这些影响随着睡眠的继续而减弱，在后半夜这些模式发生逆转。与现有的文献相反，将健康志愿者的晚餐时间从睡前5小时改为睡前1小时并没有导致夜间睡眠结构的显著不利变化。事实上，在健康志愿者中，LD与夜间开始时的深度睡眠和夜间后半部分的浅睡眠有关。这种餐后嗜睡的新表现可能对睡眠障碍患者具有治疗潜力。
Eating time and sleep habits are important modifiable behaviors that affect metabolic health, but the relationship between food intake and sleep remains incompletely understood. Observational data suggest that late food intake is associated with impaired sleep quality. We examined the effect of routine dinner (RD, 5 hours before bedtime) vs late dinner (LD, 1 hour before bedtime) on sleep architecture in healthy volunteers. This was a post hoc analysis of a randomized crossover study of RD vs LD with a fixed sleep opportunity in a laboratory setting. On each of the two visits, 20 healthy adult volunteers (10 women) received an isocaloric meal followed by overnight polysomnography. Sleep architecture over the course of the night was assessed using visual sleep staging and EEG spectral power analysis and was compared between RD and LD. We modeled the proportions of spectral power in alpha, beta, delta, and theta bands as functions of dinner timing, time of night, and their interaction with mixed-effect spline regression. Conventional sleep stages were similar between the 2 visits. LD caused a 2.5% initial increase in delta power and a reciprocal 2.7% decrease in combined alpha and beta power (p<0.0001). These effects diminished as sleep continued with a reversal of these patterns in the latter part of the night. Contrary to the existing literature, shifting dinner timing from 5 hours before sleep to 1 hour before sleep in healthy volunteers did not result in significant adverse changes in overnight sleep architecture. In fact, LD was associated with deeper sleep in the beginning of the night and lighter sleep in the latter part of the night in healthy volunteers. This novel manifestation of postprandial hypersomnia may have therapeutic potential in patients with sleep disorders.