A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women
A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women
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DOI：
10.1016/j.fertnstert.2010.05.062
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发表时间：
2011-01-01
影响因子：
6.7
通讯作者：
Hirschberg, Angelica Linden
中科院分区：
文献类型：
--
作者：
Kocoska-Maras, Ljiljana;Zethraeus, Niklas;Hirschberg, Angelica Linden
目的：测试绝经后女性性激素与认知能力之间的因果关系。我们假设与安慰剂相比，睾酮会降低言语记忆和言语流畅性，并提高空间能力。对于雌激素，我们相反地假设该治疗会提高言语流畅性和言语记忆，并降低空间能力。设计：随机、双盲、安慰剂对照、平行组试验。地点：大学医院的妇女健康临床研究单位。患者：200 名年龄 50-65 岁的健康、自然绝经后女性。干预措施：随机分组，进行 4 周的睾酮治疗（十一酸睾酮，40 毫克/天）、雌激素（口服 E-2 2 毫克/天）或安慰剂。主要结果指标：三个治疗组之间言语流畅性、言语记忆和空间能力的比较。结果：我们发现睾酮或雌激素对言语流畅性、言语记忆或空间能力没有显着影响。结论：我们的结果不支持短期睾酮或雌激素治疗对健康绝经后妇女的语言流畅性、语言记忆或空间能力有任何实质性影响。 （Fertil Steril(R) 2011；95:152-7。(C) 2011，美国生殖医学会。）
Objective: To test the causal relationship between sex hormones and cognitive skills in postmenopausal women. We hypothesized that testosterone would decrease verbal memory and verbal fluency and increase spatial ability compared with a placebo. For estrogen, we conversely hypothesized that the treatment would increase verbal fluency and verbal memory and decrease spatial ability.Design: Randomized, double-blind, placebo-controlled, parallel-group trial.Setting: Women's health clinical research unit at a university hospital.Patient(s): Two-hundred healthy, naturally postmenopausal women aged 50-65 years.Intervention(s): Randomization to 4 weeks' treatment with testosterone (testosterone undecanoate, 40 mg/day), estrogen (oral E-2 2 mg/day) or placebo.Main Outcome Measure(s): Comparisons in verbal fluency, verbal memory, and spatial ability between the three treatment groups.Result(s): We found no significant effects of testosterone or estrogen on verbal fluency, verbal memory, or spatial ability.Conclusion(s): Our results give no support for short-term testosterone or estrogen treatment having any substantial effect on verbal fluency, verbal memory, or spatial ability in healthy postmenopausal women. (Fertil Steril(R) 2011;95:152-7. (C) 2011 by American Society for Reproductive Medicine.)