Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots.
Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots.
复制标题
使用巯基琥珀酸涂层近红外量子点进行被动肿瘤靶向和成像
DOI：
10.2147/ijn.s74805
复制
发表时间：
2015
影响因子：
8
通讯作者：
Yong KT
中科院分区：
文献类型：
--
作者：
Lin G;Wang X;Yin F;Yong KT
在本文中，我们展示了制备单分散量子点（QD）作为近红外（NIR）光学探针在体内胰腺癌的靶向和成像。这些发光探针的设计涉及用配体巯基琥珀酸（MSA）官能化NIR QD，其通过增强的渗透性和保留效应靶向肿瘤部位。量子点的胶体稳定性和光学稳定性可保持>1周。在携带胰腺肿瘤的裸鼠中的体内光学成像研究显示，在静脉内注射官能化NIR QD后，探针在肿瘤部位累积>2.5小时。肿瘤标记研究表明，即使在高达50 mg/kg的剂量下，也没有证据表明对治疗动物产生有害影响。这些结果表明，工程化的MSA功能化QD可以作为早期检测癌症的诊断平台，以及在图像引导的精确手术切除肿瘤。
In this paper, we demonstrate the preparation of monodispersed quantum dots (QDs) as near-infrared (NIR) optical probes for in vivo pancreatic cancer targeting and imaging. The design of these luminescent probes involves functionalizing NIR QDs with ligand mercaptosuccinic acid (MSA), which targets the tumor site by enhanced permeability and retention effect. The colloidal and optical stability of the QDs can be maintained for >1 week. In vivo optical imaging studies in nude mice bearing pancreatic tumor show that the probes accumulate at tumor sites for >2.5 hours following intravenous injection of the functionalized NIR QDs. Tumor-labeling studies showed no evidence of harmful effects on the treated animals, even at a dose as high a ~50 mg/kg. These results demonstrate that the engineered MSA-functionalized QDs can serve as a diagnostic platform for early detection of cancer, as well as in image-guided precise surgical resection of tumors.