Prospective assessment of the occurrence of anemia in patients with heart failure: Results from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry
Prospective assessment of the occurrence of anemia in patients with heart failure: Results from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry
复制标题
DOI：
10.1016/j.ahj.2009.01.012
复制
发表时间：
2009-05-01
影响因子：
4.8
通讯作者：
Ghali, Jalal K.
中科院分区：
文献类型：
--
作者：
Adams, Kirkwood F., Jr.;Patterson, John H.;Ghali, Jalal K.
背景 尽管贫血是心力衰竭的潜在重要病理生理因素，但在未经选择的心力衰竭患者中，贫血的患病率和预测因素尚未得到充分研究。方法心力衰竭人群贫血研究 (STAMINA-HFP) 登记处前瞻性研究了心力衰竭患者贫血的患病率以及血红蛋白与健康相关生活质量和结局的关系。使用随机选择算法来减少在专科诊所或具有心力衰竭经验的社区心脏病专家诊所就诊的患者的入组过程中的偏差。在这份初始报告中，对 1,082 名登记患者中的 1,076 名患者的贫血患病率和相关性数据进行了分析，这些患者的临床特征和血红蛋白在基线时通过指尖采血测定。 结果 总体而言 (n = 1,082)，登记患者中 41% 为女性，73% 为白人，平均年龄 (+/- SD) 为 64 +/- 14 岁（社区年龄为 68 +/- 13 岁，社区年龄为 57 +/- 14 岁）。在专业场所工作 14 年，P < .001)。在患病率分析的 1,076 名患者中，平均血红蛋白为 13.3 +/- 2.1 g/dL（中位数 13.2 g/dL）； 34% 的人患有贫血（根据世界卫生组织的标准定义）。年龄确定了有贫血风险的患者，其中 40% 的患者> 70 岁。结论 STAMINA-HFP 登记处的初步结果表明，贫血是未经选择的心力衰竭门诊患者的常见合并症。鉴于贫血与心力衰竭的不良后果密切相关，本研究支持进一步研究贫血作为心力衰竭治疗目标的重要性。 （Am Heart J 2009；157：926-32。）
Background Although a potentially important pathophysiologic factor in heart failure, the prevalence and predictors of anemia have not been well studied in unselected patients with heart failure.Methods The Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry prospectively studied the prevalence of anemia and the relationship of hemoglobin to health-related quality of life and outcomes among patients with heart failure. A random selection algorithm was used to reduce bias during enrollment of patients seen in specialty clinics or clinics of community cardiologists with experience in heart failure. In this initial report, data on prevalence and correlates of anemia were analyzed in 1,076 of the 1,082 registry patients who had clinical characteristics and hemoglobin determined by finger-stick at baseline.Results Overall (n = 1,082), the registry patients were 41% female and 73% white with a mean age (+/- SD) of 64 +/- 14 years (68 +/- 13 years in community and 57 +/- 14 years in specialty sites, P < .001). Among the 1,076 patients in the prevalence analysis, mean hemoglobin was 13.3 +/- 2.1 g/dL (median 13.2 g/dL); and anemia (defined by World Health Organization criteria) was present in 34%. Age identified patients at risk for anemia, with 40% of patients > 70 years affected.Conclusions Initial results from the STAMINA-HFP Registry suggest that anemia is a common comorbidity in unselected outpatients with heart failure. Given the strong association of anemia with adverse outcomes in heart failure, this study supports further investigation concerning the importance of anemia as a therapeutic target in this condition. (Am Heart J 2009;157:926-32.)