Acrolein, an environmental toxicant and its applications to in vivo and in vitro atherosclerosis models: An update.
Acrolein, an environmental toxicant and its applications to in vivo and in vitro atherosclerosis models: An update.
复制标题
丙烯醛，一种环境毒物及其在体内和体外动脉粥样硬化模型中的应用：更新。
DOI：
10.1016/j.etap.2022.103890
复制
发表时间：
2022
影响因子：
4.3
通讯作者：
Kim,JaeKyeom
中科院分区：
文献类型：
--
作者：
Crowley,LianaN;Le,BrandyL;Cicalo,Cara;Brown,Justin;Li,Yali;Kim,YoungJun;Lee,JinHyup;Pan,JeongHoon;Lennon,ShannonL;Han,BokKyung;Kim,JaeKyeom
心血管疾病是全世界最主要的死亡原因，是一个总括性的疾病术语，包括涉及心脏和循环系统的许多疾病，包括动脉粥样硬化。动脉粥样硬化是心血管疾病的主要原因，是由斑块积聚和血管狭窄引起的。流行病学研究表明，环境污染物与动脉粥样硬化疾病的进展有关。在许多环境污染物中，丙烯醛（Acr）是一种丰富的反应性醛，并且普遍存在于香烟烟雾以及食品（例如，过热的油和酒）。尽管它的普遍存在和对心血管疾病的病因学的潜在影响，已经取得了有限的共识方面的Acr暴露条件，以诱导体内动脉粥样硬化。这篇简短的综述总结了使用Acr的体内动脉粥样硬化模型，以研究动脉粥样硬化相关的生化和表型变化以及涉及Acr和动脉粥样硬化的体外机制研究。
Cardiovascular disease, the foremost cause of death worldwide, is an overarching disease term that encompasses a number of disorders involving the heart and circulatory system, including atherosclerosis. Atherosclerosis is a primary cause of cardiovascular diseases and is caused by buildup of plaque and narrowing of blood vessels. Epidemiological studies have suggested that environmental pollutants are implicated in atherosclerosis disease progression. Among many environmental pollutants, acrolein (Acr) is an abundant reactive aldehyde and is ubiquitously present in cigarette smoke as well as food products (e.g., overheated oils and wine). Despite its ubiquitous presence and potential impact on the etiology of cardiovascular disease, a limited consensus has been made in regard to Acr exposure conditions to induce atherosclerosis in vivo. This mini-review summarizes in vivo atherosclerosis models using Acr to investigate biochemical and phenotypic changes related to atherosclerosis and in vitro mechanistic studies involving Acr and atherosclerosis.