Pressure Controlled Clamp Using Shape Memory Alloy for Minimal Vessel Invasion in Blood Flow Occlusion
Pressure Controlled Clamp Using Shape Memory Alloy for Minimal Vessel Invasion in Blood Flow Occlusion
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DOI：
10.5761/atcs.oa.11.01873
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发表时间：
2013-02-01
影响因子：
1.3
通讯作者：
Shimizu, Yoshinaka
中科院分区：
文献类型：
--
作者：
Zhang, Ye;Kanetaka, Hiroyasu;Shimizu, Yoshinaka
目的：血管夹闭后的血管损伤可能影响外科手术的成功。利用形状记忆合金（SMA）的超弹性特性，设计了一种新型的压力控制血管夹（SMA夹），以实现无创血管闭塞。方法：采用夹持压力分析系统，通过夹闭猪颈动脉，测量SMA夹（实验组）和普通夹（对照组）的载荷-位移曲线，分析SMA夹的生物学效应。为观察SMA夹与常规夹对血管的损伤，采用伊文思蓝染色法和ElasticaMassion染色法分别对猪颈动脉夹闭15 min后的组织切片进行组织学观察。对照组血管壁伊文氏蓝染色的损伤区随压力增加而增大。实验组的面积小于对照组。实验组除图尼卡内膜有轻度压缩性损伤外，组织切片未见明显改变。结论：本实验表明SMA夹具有独特的力学性能，可以在不损伤血管的情况下使用。该压力控制钳可作为临床器械的一种选择，以提高手术安全性。
Purpose: Vessel damage after clamping may affect the success of surgical operations. A new pressure controlled clamp (SMA clamp) was designed using super elastic property of shape memory alloy (SMA) to realize atraumatic vessel occlusion. The ability and biological effect of the SMA clamp to control pressure was investigated in vivo.Methods: The loading-displacement curves of the SMA clamps (experimental group) and conventional clamp (control group) by occlusion of pig carotid arteries were evaluated using a clamping-pressure analyzing system. To investigate macroscopically and histologically the vessel damage of the SMA and conventional clamps, pig carotid arteries were stained with Evan's blue and its histological sections were stained with Elastica Massion after clamping for fifteen minutes.Results: Constant value was shown in the loading-displacement curve of SMA clamp. In the control group, damaged area stained with Evan's blue in the vessel wall showed enlargement with the pressure increasing. Less areas in experimental groups are observed than that in the control group. Histological section in the experimental group showed no obvious except a slight compressive damage in the tunica intima. In the control group, vessel wall showed irreversible damages.Conclusions: This experiment indicated that the SMA clamp, which has a unique mechanical property, can be used without vessels damage. This pressure controlled clamp can be a selection in clinical apparatus to improve surgical safety.