Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease
Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2015.03.001
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发表时间：
2015-06-01
影响因子：
4.2
通讯作者：
Fortea, Juan
中科院分区：
文献类型：
--
作者：
Alcolea, Daniel;Vilaplana, Eduard;Fortea, Juan
脑脊液YKL-40已被描述为神经胶质炎症的标志物。我们的目的是研究YKL-40与脑结构的关系及其与核心阿尔茨海默病（AD）生物标志物的相互作用。我们测量了80名认知正常对照和27名遗忘型轻度认知障碍患者的皮质厚度（CTh）和脑脊液生物标志物（淀粉样蛋白β 1-42 [A β 42]，总tau，p-tau和YKL-40）。受试者被分类为A β 42+（550 pg/mL）。CTh差异图来自整个样本和临床组内的相互作用和相关性分析。YKL-40与神经变性标志物（总tau和p-tau）之间存在强相关性。在整个样本中，我们发现在A β 42+受试者的AD易发区，YKL-40和CTh之间呈负相关，但在A β 42参与者中不相关。我们的研究结果表明，YKL-40可以跟踪与tau蛋白相关的神经退行性疾病的存在下，AD的病理生理过程的炎症过程。(C)2015 Elsevier Inc. All rights reserved.
Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-beta 1-42 [A beta 42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as A beta 42+ (550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in A beta 42+ subjects but not in A beta 42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process. (C) 2015 Elsevier Inc. All rights reserved.