Vitamin K2 suppresses malignancy of HuH7 hepatoma cells via inhibition of connexin 43
Vitamin K2 suppresses malignancy of HuH7 hepatoma cells via inhibition of connexin 43
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DOI：
10.1016/j.canlet.2007.12.019
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发表时间：
2008-05-08
期刊：
影响因子：
9.7
通讯作者：
Morita, Ikuo
中科院分区：
文献类型：
--
作者：
Kaneda, Makoto;Zhang, Dan;Morita, Ikuo
维生素K-2（VK 2）在肝癌中的抗癌潜力已引起相当大的关注，但其潜在机制尚不清楚。用VK 2处理HuH 7肝癌细胞产生正常的肝脏表型。用VK 2处理细胞后，间隙连接细胞间通讯活性增加，伴随着连接蛋白32（Cx 32）的上调，其主要在正常肝细胞中表达。相反，Cx43表达被抑制。此外，VK 2对Cx 32的影响被Cx43的过表达所消除。综上所述，我们认为VK 2的抗肿瘤作用至少部分是由于Cx43启动子活性的降低。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
The anti-cancer potential of vitamin K-2 (VK2) in hepatoma has gained considerable attention but the underlying mechanisms are unclear. Treatment of HuH7 hepatoma cells with VK2 produced a normal liver phenotype. Following treatment of cells with VK2, there was an increase in gap junctional intercellular communication activity, accompanied by up-regulation of connexin 32 (Cx32), dominantly expressed in normal hepatocyte. In contrast, Cx43 expression was inhibited. Moreover, the effect of VK2 on Cx32 was abolished by over-expression of Cx43. Taken together, we propose that the anti-tumor effect of VK2 is at least partly due to a decrease in Cx43 promoter activity. (C) 2007 Elsevier Ireland Ltd. All rights reserved.