DEVELOPMENT OF THE DIENCEPHALON IN THE RAT .4. QUANTITATIVE STUDY OF THE TIME OF ORIGIN OF NEURONS AND THE INTER-NUCLEAR CHRONOLOGICAL GRADIENTS IN THE THALAMUS
DEVELOPMENT OF THE DIENCEPHALON IN THE RAT .4. QUANTITATIVE STUDY OF THE TIME OF ORIGIN OF NEURONS AND THE INTER-NUCLEAR CHRONOLOGICAL GRADIENTS IN THE THALAMUS
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DOI：
10.1002/cne.901880308
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发表时间：
1979-01-01
影响因子：
2.5
通讯作者：
BAYER, SA
中科院分区：
文献类型：
--
作者：
ALTMAN, J;BAYER, SA
妊娠大鼠组从妊娠第13、14天（E13 + 14）至出生前（E21 + 22）连续每日注射2次3h -胸腺嘧啶。通过这种逐渐延迟的综合标记程序，确定了上皮体、丘脑和腹侧丘脑核中神经元的起源时间。交错带、丘脑底核、网状核、后核和腹侧外侧膝状核是最早出现的神经元（E13或之前至E15）。外侧缰核的神经元在E13-16天产生。内侧膝状核和外侧膝状核的神经元、腹基底核和腹外侧核复合体以及外侧核、后部的神经元在E14-15天迅速出现；内侧膝状核在E14天出现高峰，其余在E15天出现高峰。感觉传递核内侧有一组边界不清的神经元，在第E15 ~ 16天出现明显，在第E15天出现高峰；这些可能代表层内核。下一组在E15-16天产生，但在E16天形成高峰：包括前腹侧核、前嗅侧核、前内侧核和中嗅侧核。菱形核、束连核、束旁核和室旁核、前部核紧随其后（E16-17）。内侧系带核形成的时间较长（E15-19）。由于发育时间较长，外侧核和内侧核更像下丘脑核而不是背丘脑核。
Groups of pregnant rats were injected with 2 successive daily doses of 3H-thymidine from gestational days 13 and 14 (E13 + 14) until the day before birth (E21 + 22). With this progressively delayed comprehensive labeling procedure, the time of origin of neurons in the nuclei of the epithalamus, thalamus, and ventral thalamus were determined. The zona incerta, subthalamic nucleus, reticular nucleus, posterior nucleus and ventral lateral geniculate nucleus are composed of the earliest arising neurons (E13, or before, to E15). The neurons of the lateral habenular nucleus are produced between days E13-16. The neurons of the medial geniculate and lateral geniculate nuclei, the ventrobasal and ventrolateral complexes, and the nucleus lateralis, pars posterior, arise rapidly on days E14-15; the medial geniculate nucleus with a peak on day E14, the others with a peak on day E15. Neurons of a group of nuclei, with ill-defined boundaries medial to the sensory relay nuclei, arise apparently on days E15-16, with a peak on day E15; these may represent the intralaminar nuclei. The next group is generated on days E15-16 but with peak formation time on day E16: this includes the anteroventral, anterodorsal, anteromedial and mediodorsal nuclei. The rhomboid, reuniens and paratenial nuclei, and the paraventricular nucleus, pars anterior, arise next (E16-17). The medial habenular nucleus forms last and over a protracted period (E15-19). With their lengthy generation time the lateral and medial habenular nuclei resemble more the nuclei of the hypothalamus than the nuclei of the dorsal thalamus.