Feasibility, acceptability, and preliminary efficacy of cognitive processing therapy in Japanese patients with posttraumatic stress disorder
Feasibility, acceptability, and preliminary efficacy of cognitive processing therapy in Japanese patients with posttraumatic stress disorder
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日本创伤后应激障碍患者认知加工治疗的可行性、可接受性和初步疗效
DOI：
10.1002/jts.22901
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发表时间：
2022
影响因子：
3.3
通讯作者：
Horikoshi Masaru
中科院分区：
文献类型：
--
作者：
Takagishi Yuriko;Ito Masaya;Kanie Ayako;Morita Nobuaki;Makino Miyuki;Katayanagi Akiko;Sato Tamae;Imamura Fumi;Nakajima Satomi;Oe Yuki;Kashimura Masami;Kikuchi Akiko;Narisawa Tomomi;Horikoshi Masaru
认知加工疗法（CPT）是创伤后应激障碍（PTSD）最广泛测试的循证疗法之一。然而，大多数关于CPT的研究都是在西方文化背景下进行的。这项开放标签、单组试验研究了CPT治疗日本PTSD患者的可行性、可接受性和初步疗效。共有25名门诊患者接受了12次CPT治疗。主要结局是使用临床医生管理的PTSD量表（CAPS-IV）评估PTSD症状;次要结局包括主观PTSD严重程度、抑郁和焦虑症状、创伤相关认知和主观生活质量的评估。在治疗前（即，基线）、治疗后以及6个月和12个月随访。参与者平均参加了13次CPT（SD= 1.38），完成率为96.0%。发生1起严重不良事件（住院）。从基线至治疗完成，发现CAPS-IV评分的受试者内标准化平均差异显著，g= −2.28，95%CI [−3.00，−1.56]; 6个月随访，g= −2.95，95%CI [−3.79，−2.12]; 12个月随访，g= −2.15，95%CI [−2.89，−1.41]。在次要结局中发现了中度至重度效应，gs = −0.77至−2.45。这些结果支持CPT在日本临床环境中的可行性、可接受性和初步疗效。
Cognitive processing therapy (CPT) is one of the most widely tested evidence‐based treatments for posttraumatic stress disorder (PTSD). However, most studies on CPT have been conducted in Western cultural settings. This open‐label, single‐arm trial investigated the feasibility, acceptability, and preliminary efficacy of CPT for treating Japanese patients with PTSD. A total of 25 outpatients underwent 12 CPT sessions. The primary outcome was the assessment of PTSD symptoms using the Clinician‐Administered PTSD Scale forDSM‐IV(CAPS‐IV); secondary outcomes included the assessment of subjective PTSD severity, depressive and anxiety symptoms, trauma‐related cognitions, and subjective quality of life. All outcomes were evaluated at pretreatment (i.e., baseline), posttreatment, and 6‐ and 12‐month follow‐ups. On average, participants attended 13 sessions of CPT (SD= 1.38), with a completion rate of 96.0%. One serious adverse event (hospitalization) occurred. Significant within‐subjects standardized mean differences in CAPS‐IV scores were found from baseline to treatment completion,g= −2.28, 95% CI [−3.00, −1.56]; 6‐month follow‐up,g= −2.95, 95% CI [−3.79, −2.12]; and 12‐month follow‐up,g= −2.15, 95% CI [−2.89, −1.41]. Moderate‐to‐large effects,gs = −0.77 to −2.45, were found on secondary outcomes. These findings support the feasibility, acceptability, and preliminary efficacy of CPT in a Japanese clinical setting.