Lipofuscin pigment over benign and malignant choroidal tumors.
Lipofuscin pigment over benign and malignant choroidal tumors.
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良性和恶性脉络膜肿瘤的脂褐素色素。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
W. Annesley
中科院分区：
文献类型：
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作者：
J. Shields;M. Rodrigues;L. Sarin;W. Tasman;W. Annesley
这项研究表明，脂褐素色素可以积累在RPE细胞和巨噬细胞在几种类型的良性和恶性脉络膜肿瘤。然而，色素的颜色随潜在病变的性质和颜色而变化。在深色素性肿瘤表面，脂褐素色素可呈橙子，而在无色素性病变表面，脂褐素色素可呈棕色或红棕色。在血管肿瘤（例如脉络膜血管瘤）的表面，脂褐素在眼底镜下几乎不可见，但可以通过荧光素血管造影术显示。虽然这种色素积聚的存在提示恶性黑色素瘤，但它不是诊断性的，也可能发生在良性的模拟病变上。
This study has shown that lipofuscin pigment may accumulate in RPE cells and macrophages over several types of benign and malignant choroidal tumors. The color of the pigment, however, varies with the nature and color of the underlying lesion. On the surface of deeply pigmented tumors the lipofuscin pigment may produce an orange color, whereas over amelanotic lesions it may appear brown or reddish-brown. On the surface of vascular tumors, such as choroidal hemangiomas, the lipofuscin is almost invisible ophthalmoscopically but may be demonstrated with fluorescein angiography. Although the presence of such pigment accumulation is suggestive of a malignant melanoma, it is not diagnostic and may occur over benign simulating lesions as well.