Can Activation of Coagulation and Impairment of Fibrinolysis in Patients With Anxiety and Depression Be Reversed After Improvement of Psychiatric Symptoms? Results of a Pilot Study
Can Activation of Coagulation and Impairment of Fibrinolysis in Patients With Anxiety and Depression Be Reversed After Improvement of Psychiatric Symptoms? Results of a Pilot Study
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DOI：
10.1097/nmd.0b013e3182613fa5
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发表时间：
2012-08-01
影响因子：
1.9
通讯作者：
Harbrecht, Ursula
中科院分区：
文献类型：
--
作者：
Geiser, Franziska;Gessler, Katharina;Harbrecht, Ursula
焦虑和抑郁与凝血激活和纤溶损伤有关。这项研究解决了在心理治疗和精神症状改善后这些发现是否被逆转的问题。对12例患者进行强化住院心理治疗后1 ~ 3年的凝血和纤溶三个因素以及焦虑和抑郁水平进行重新评估。患者表现出严重焦虑障碍和共病抑郁障碍的显著改善。同时，我们发现因子VII和纤溶酶原激活物抑制剂显著降低。我们的结论是，严重焦虑和抑郁的减少可能与这些心理状态的促凝作用（凝血激活和纤溶损伤）的逆转有关。由于本初步研究样本量小，需要进一步研究。
Anxiety and depression are associated with an activation of coagulation and impairment of fibrinolysis. This study addresses the question whether these findings are reversed after psychotherapy and improvement of psychiatric symptoms. Three factors of coagulation and fibrinolysis as well as level of anxiety and depression were reassessed in 12 patients 1 to 3 years after intensive inpatient psychotherapy. The patients showed a substantial improvement of their severe anxiety disorder and comorbid depressive disorder. Simultaneously, we found a significant decrease in factor VII and plasminogen activator inhibitor. We conclude that reduction of severe anxiety and depression may be associated with a reversal of the procoagulant effect (activation of coagulation and impairment of fibrinolysis) of these psychological states. Because of the small sample size of this pilot study, further research is needed.