Mechanisms of cellular plasticity in cerebral perivascular region.
Mechanisms of cellular plasticity in cerebral perivascular region.
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DOI：
10.1016/bs.pbr.2016.03.005
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发表时间：
2016
影响因子：
--
通讯作者：
Arai K
中科院分区：
文献类型：
--
作者：
Egawa N;Lok J;Arai K
脑血管系统与神经元协同作用以维持脑功能。这种神经血管耦合，或脑内皮细胞和神经元之间的营养耦合，现在被广泛接受为绘制大脑活动的标志物。神经血管偶联在血管周围区域最活跃，在该区域中，神经血管单元内有足够的细胞-细胞相互作用的机会。细胞之间的营养耦合维持神经血管功能和细胞可塑性。最近的研究表明，即使是成年人的大脑也含有多种不同谱系的干细胞，这可能通过这些干细胞群体之间的分化过程提供细胞可塑性。在这一章中，我们提供了一个概述的过程中，神经血管成分有助于在脑血管周围区域的细胞可塑性，专注于在成人大脑中的细胞-细胞相互作用的机制。
Brain vasculature acts in synergism with neurons to maintain brain function. This neurovascular coupling, or trophic coupling between cerebral endothelium and neuron, is now well-accepted as a marker for mapping brain activity. Neurovascular coupling is most active in the perivascular region, in which there are ample opportunities for cell-cell interactions within the neurovascular unit. This trophic coupling between cells maintains neurovascular function and cellular plasticity. Recent studies have revealed that even adult brains contain multiple stem cells of various lineages, which may provide cellular plasticity through the process of differentiation among these stem cell populations. In this chapter, we provide an overview of the process by which neurovascular components contribute to cellular plasticity in the cerebral perivascular regions, focusing on mechanisms of cell-cell interaction in adult brain.