Cholecystokinin conditioning in rats: ontogenetic determinants.
Cholecystokinin conditioning in rats: ontogenetic determinants.
复制标题
大鼠胆囊收缩素调理：个体发育决定因素。
DOI：
10.1037//0735-7044.104.1.199
复制
发表时间：
1990
影响因子：
1.9
通讯作者：
Blass,EM
中科院分区：
文献类型：
--
作者：
Weller,A;Blass,EM
腹腔注射低剂量（0.12-2.0 μg/kg）胆囊收缩素八肽（CCK）有助于新生和断奶大鼠条件性气味偏好的形成。暴露于一种新气味与注射 CCK 相结合，24 小时后评估大鼠的嗅觉选择。与注射赋形剂的同窝小鼠相比，5、11 和 22 天龄的大鼠更喜欢先前与 CCK 相关的气味。相比之下，CCK 无法支持 28 日龄大鼠的嗅觉调节，无论它们是 (a) 断奶并独立饲养，(b) 与母鼠和哺乳鼠一起生活，还是 (c) 只喂牛奶。成年大鼠在 CCK 作为无条件刺激时也没有建立气味偏好。因此，CCK从阳性到中性的影响可能发生在大鼠出生后第4周，并且可能与断奶最后阶段发生的成熟变化有关。（PsycINFO数据库记录（c）2016 APA，保留所有权利）
Low doses (0.12–2.0 μg/kg) of cholecystokinin octapeptide (CCK), administered intraperitoneally, support the formation of conditioned odor preference in neonatal and weanling rats. Exposure to a novel odor was paired with CCK injection, and the rats' olfactory choices were assessed 24 hr later. Rats at 5, 11, and 22 days of age preferred the odor previously associated with CCK, compared with vehicle-injected littermates. In contrast, CCK failed to support olfactory conditioning in 28-day-old rats, whether they were (a) weaned and independently housed,(b) residing with the dam and suckling, or (c) fed only milk. Adult rats also did not establish an odor preference with CCK as the unconditioned stimulus. Thus, CCK's changing impact from positive to neutral probably occurs during the rats' 4th postnatal week and may be related to maturational changes occurring during the final stages of weaning.(PsycINFO Database Record (c) 2016 APA, all rights reserved)