Relationship between IL1 gene polymorphisms and periodontal disease in Japanese women.
Relationship between IL1 gene polymorphisms and periodontal disease in Japanese women.
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日本女性IL1基因多态性与牙周病的关系
DOI：
10.1089/dna.2013.2202
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Arakawa M.
中科院分区：
文献类型：
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作者：
Tanaka K;Miyake Y;Hanioka T;Arakawa M.
关于IL 1A和/或IL 1B多态性与牙周病之间关系的流行病学证据不一致。我们调查了编码白细胞介素（IL）-1α（rs 1800587）和IL-1β（rs 1143634和rs 16944）的基因中的三个IL-1单核苷酸多态性（SNP）与日本年轻女性牙周病风险之间的关系。对1150名女性进行了病例对照研究，其中131名受试者至少有一颗牙齿的牙周袋深度为4 mm或更深，1019名牙周健康对照。与SNP rs 16944 GG基因型女性对照组相比，GA基因型女性患牙周病的风险显著降低，而AA基因型与牙周病之间无显著关系。SNP rs 1800587和rs 1143634与牙周病之间无明显相关性。我们的研究没有发现任何证据表明IL 1多态性与吸烟之间存在相互作用。这项研究的结果表明，在日本年轻女性中，IL 1 rs 16944的杂合变异基因型与牙周病风险降低显著相关。吸烟并没有显著改变研究中的基因-疾病关联。
Epidemiological evidence on the relationship betweenIL1Aand/orIL1Bpolymorphisms and periodontal disease is inconsistent. We investigated associations between threeIL1single-nucleotide polymorphisms (SNPs) in genes encoding interleukin (IL) -1α (rs1800587) and IL-1β (rs1143634 and rs16944) and the risk of periodontal disease among young Japanese women. A case–control study was performed with a total of 1150 women, including 131 subjects who had at least one tooth with a probing pocket depth of 4 mm or deeper and 1019 periodontally healthy controls. Compared with a reference group of women with the GG genotype of SNP rs16944, those with the GA genotype had a significantly reduced risk of periodontal disease, while there was no significant relationship between the AA genotype and periodontal disease. No evident relationships were observed between SNP rs1800587 or rs1143634 and periodontal disease. Our study did not reveal any evidence of interaction between theIL1polymorphisms and smoking. The results of this study showed that the heterozygous variant genotype of theIL1rs16944 was significantly associated with a reduced risk of periodontal disease in young Japanese women. Smoking did not significantly modify the gene–disease associations under study.