Fabricating a sustained releaser of heparin using SBA-15 mesoporous silica
Fabricating a sustained releaser of heparin using SBA-15 mesoporous silica
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使用SBA-15介孔二氧化硅制备肝素缓释剂
DOI：
10.1039/c3tb21092h
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发表时间：
2014-01-01
影响因子：
7
通讯作者：
Zhu, Jian Hua
中科院分区：
文献类型：
--
作者：
Qian, Wen Juan;Wan, Mi Mi;Zhu, Jian Hua
足够量和长时间持续释放肝素是推动功能材料开发的挑战。本论文选择SBA-15介孔氧化硅为载体，研究其对肝素缓释的影响。原位碳化的模板在合成的样品中，使SBA-15具有狭窄的通道与粗糙的表面，而修改（氨丙基）三乙氧基硅烷（APTES）通过一锅合成提供SBA-15与正电荷吸引肝素通过静电相互作用。采用X射线粉末衍射（XRD）、氮气吸附-脱附和电子显微镜技术对改性后的SBA-15样品进行结构表征，并评价其对肝素的吸附和释放性能。这些修饰改善了肝素在SBA-15中的吸附，从而促进其持续释放，将释放平衡时间延长至60天。其中，APTES修饰的SBA-15样品对肝素的截留量是母体SBA-15的3倍，释放率提高到80%（SBA-15为38%），实现了迄今为止最好的肝素释放控制性能。
The sustained release of heparin in sufficient amounts and over long time is a challenge to drive the development of functional materials. In this paper SBA-15 mesoporous silica is selected in the search for a favorable morphology and optimized surface state for the sustained release of heparin. In situ carbonization of the template in the as-synthesized sample enables SBA-15 to possess narrowed channels with rougher surfaces, while modification with (aminopropyl)triethoxysilane (APTES) through a one-pot synthesis offers SBA-15 with positive charges to attract heparin through electro-static interactions. The structure of modified SBA-15 samples is assessed with XRD (powder X-ray diffraction analysis), nitrogen adsorption-desorption and electron microscopy techniques, and their performance is evaluated in adsorption and release of heparin. These modifications improve the heparin adsorption in SBA-15 and thus promote its sustained release, prolonging the release-equilibrium time up to 60 days. Among them, the SBA-15 sample modified with APTES can trap three times as much heparin as the parent SBA-15, and the release ratio is elevated to 80% (that of SBA-15 is 38%), realizing the best performance of controlling heparin release to date.