STUDIES ON DESOXY-CORTICOSTERONE1,2
STUDIES ON DESOXY-CORTICOSTERONE1,2
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去氧皮质酮的研究1,2
DOI：
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发表时间：
1939
期刊：
影响因子：
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通讯作者：
H. Eisenberg
中科院分区：
文献类型：
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作者：
G. W. Thorn;H. Eisenberg
1937年，STEIGER和REICHSTEIN(1)宣布从stig-masterol制备醋酸羟皮质酮（Δ4-pregnene-21-ol-3, 20-dione, acetate）。最近，Reichstein(2)成功地从牛肉肾上腺提取物中分离出去氧皮质酮。在之前的一篇文章中，我们比较了醋酸去氧皮质酮（合成）和肾上腺皮质提取物在正常犬体内产生钠和氯潴留的功效，以及在肾上腺素失调的犬体内维持电解质平衡的功效。在本报告中，我们研究了每天单次皮下注射油中去氧皮质酮醋酸酯溶液在维持喂食低钠和氯含量饮食的肾上腺切除狗的有效性。雄性狗（大约10公斤）被关在新陈代谢笼子里，喂食由350至400克绞碎牛肉和50毫升辐照蒸发牛奶组成的固定饮食
IN 1937 STEIGER AND REICHSTEIN (1) announced the preparation of desoxy, corticosterone acetate (Δ4-pregnene-21-ol-3, 20-dione, acetate) from stig-masterol. Recently, Reichstein (2) has succeeded in isolating desoxy-cortico, sterone from an extract of beef adrenal. In a previous publication (3) we have compared the efficacy of desoxy-corticosterone acetate (synthetic) and adrenal cortical extract in producing a retention of sodium and chloride in normal dogs and in maintaining the electrolyte balance of an adrenalec, tomized dog. In the present report we have studied the effectiveness of single daily subcutaneous injections of a solution of desoxy-corticosterone acetate in oil in maintaining adrenalectomised dogs fed a diet of low sodium and chloride content. Male dogs (approximately 10 kg) were maintained in metabolism cages and fed a constant diet composed of 350 to 400 gm. of ground beef to which was added 50 cc. of irradiated evaporated milk.3