The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes
The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes
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DOI：
10.14670/hh-25.445
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发表时间：
2010-04-01
影响因子：
2
通讯作者：
Takano, Yasuo
中科院分区：
文献类型：
--
作者：
Zheng, Hua-chuan;Zheng, Yu-shuang;Takano, Yasuo
日本是胃癌的高危地区，其发病阶段相对较早，预后良好。为了阐明日本胃腺癌的病理学行为和预后，我们分析了不同WHO癌症亚型的临床病理特征。使用免疫组织化学和组织微阵列检测ki-67、CPP32、p53、FHIT、maspin、parafascin、GRP78、GRP94、EMMPRIN、VEGF、P-GSK3 beta-ser(9)、肌成束蛋白、cortactin、Arp2、Arp3 MUC-2、MUC-5AC和MUC-6的表达。大多数病例为高分化、低分化或中分化亚型，少数为乳头状或印戒细胞癌（SRC）。低分化癌或SRC癌患者主要是年轻人和女性。低分化癌和粘液癌体积较大，侵犯较深，静脉或淋巴管侵犯较多，淋巴结受累和腹膜播散频繁，或分期较高。 SRC 组的 ki-67、CPP32、p53、副纤维蛋白、GRP78、GRP94、P-GSK3 beta-ser(9)、VEGF 或 cortactin 表达较弱。中分化亚型的FHIT和Arp3阳性表达较低。低分化组CPP32、EMMPRIN、MUC-2、MUC-5AC和MUC-6表达较弱。生存分析表明，低分化或粘液性亚型患者的累积生存率低于乳头状癌、高分化、中分化或SRC癌患者（P
Japan is a high-risk region for gastric carcinoma with a comparatively early stage and favorable prognosis. To clarify the pathobiological behaviors and prognosis of Japanese gastric adenocarcinoma, we analyzed the clinicopathological characteristics of different WHO subtypes of carcinomas. The expression of ki-67, CPP32, p53, FHIT, maspin, parafibromin, GRP78, GRP94, EMMPRIN, VEGF, P-GSK3 beta-ser(9), fascin, cortactin, Arp2, Arp3 MUC-2, MUC-5AC and MUC-6 was examined using immunohistochemistry and tissue microarrays. The majority of cases were well-, poorly-, or moderately-differentiated subtype, whereas the minority were papillary or signet ring cell carcinoma (SRC). Patients with poorly-differentiated or SRC carcinoma were predominantly young and female. Poorly-differentiated and mucinous carcinomas were larger, with deeper invasion, more venous or lymphatic invasion, frequent lymph node involvement and peritoneal dissemination, or higher staging. The SRC group exhibited weaker expression of ki-67, CPP32, p53, parafibromin, GRP78, GRP94, P-GSK3 beta-ser(9), VEGF or cortactin. The moderately-differentiated subtype exhibited lower expression of FHIT and Arp3 positivity. The poorly-differentiated group showed weaker expression of CPP32, EMMPRIN, MUC-2, MUC-5AC, and MUC-6. Survival analysis indicated that the patients with poorly-differentiated or mucinous subtypes had a lower cumulative survival rate than those with papillary, well-, moderately-differentiated, or SRC carcinomas (P