Functional near-infrared spectroscopy study on tonic pain activation by cold pressor test
Functional near-infrared spectroscopy study on tonic pain activation by cold pressor test
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DOI：
10.1117/1.nph.4.1.015004
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发表时间：
2017-01-01
期刊：
影响因子：
5.3
通讯作者：
Pourrezaei, Kambiz
中科院分区：
文献类型：
--
作者：
Barati, Zeinab;Zakeri, Issa;Pourrezaei, Kambiz
功能近红外光谱（fNIRS）最近被建议用于监测皮质血流动力学反应的实验和临床急性疼痛。然而，血流动力学反应的紧张性，有害的冷刺激，其与主观疼痛感觉的关系并没有完全的特点。我们研究了不同强度的冷加压试验（CPT）的痛阈和耐受性与诱发血流动力学反应之间的关系，并探讨了性别效应。21名健康个体（10名男性和11名女性）在1 ℃、5 ℃、10 ℃和15 ℃下进行了4次CPT。通过两个“远”和两个“近”通道连续测量前额的脱氧血红蛋白（HHb）和氧合血红蛋白（HbO（2）），以及疼痛评分、阈值和耐受性。我们发现，在受试者内，疼痛阈值和右额叶区域的即时HbO（2）反应之间存在显著相关性。性别差异和不对称激活观察到的“远”通道，但不是“近”通道，表明半球的偏好反应有害的冷刺激。在疼痛阈值、耐受性或评分方面没有发现性别差异。这项研究增加了文献的主体，建议使用fNIRS进行床边疼痛评估，除了行为和主观措施，全面的，多模式的疼痛管理。(c)2017年，美国光电仪器工程师学会（SPIE）。
Functional near-infrared spectroscopy (fNIRS) has recently been suggested for monitoring cortical hemodynamic response to experimental and clinical acute pain. However, the hemodynamic response to a tonic, noxious cold stimulus, and its relation with subjective pain sensation is not fully characterized. We investigated the relationship between pain threshold and tolerance and the evoked hemodynamic response to cold pressor tests (CPTs) at varying intensities and explored the gender effect. Twenty-one healthy individuals (10 males and 11 females) performed four CPTs at 1 degrees C, 5 degrees C, 10 degrees C, and 15 degrees C. Deoxyhemoglobin (HHb) and oxyhemoglobin (HbO(2)) were measured continuously on the forehead by two "far" and two "near" channels in addition to pain scores, threshold, and tolerance. We found a significant within-subject correlation between pain threshold and the immediate HbO(2) response at the right frontal region. Gender difference and asymmetrical activation were observed in the "far" channels but not the "near" channels, suggesting a hemispheric preference in response to noxious cold stimuli. No gender difference was found in pain threshold, tolerance, or scores. This research adds to the body of literature suggesting the use of fNIRS for bedside assessment of pain in addition to behavioral and subjective measures for comprehensive, multimodal pain management. (c) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE).