Sarcopenia and Mortality among Older Nursing Home Residents
Sarcopenia and Mortality among Older Nursing Home Residents
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DOI：
10.1016/j.jamda.2011.07.004
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发表时间：
2012-02-01
影响因子：
7.6
通讯作者：
Onder, Graziano
中科院分区：
文献类型：
--
作者：
Landi, Francesco;Liperoti, Rosa;Onder, Graziano
背景和目的：肌肉减少症已被认为是年老个体虚弱和预后不良的可靠标志。目前，没有关于疗养院人群中肌肉减少症的数据。本研究的目的是探讨意大利养老院70岁及以上老年人群体中肌肉减少症与全因死亡率之间的关系。本研究在2010年8月1日至2010年9月30日期间居住在罗马天主教大学教学疗养院的70岁及以上的所有受试者（n = 122）中进行，2010.根据欧洲老年人肌肉减少症工作组（EWGSOP）的说法，肌肉减少症是在低肌肉质量加上低肌肉力量或低体能的情况下诊断出来的。主要结局指标为6个月后的生存率。结果：40名居民（32.8%）被确定为受肌肉减少症。这种情况在男性（68%）中比女性（21%）更常见。随访期间，26例（21.3%）患者死亡。在调整了年龄、性别、脑血管疾病、骨关节炎、慢性阻塞性肺病、日常生活能力障碍和体重指数后，与没有肌肉减少症的居民相比，（调整后的风险比为2.34; 95%置信区间为1.04-5.24）。目前的研究表明，在生活在疗养院的受试者中，肌肉减少症非常普遍，并与全因死亡的风险显著增加有关。目前的研究结果支持的可能性，肌肉减少症有一个独立的影响生存之间的养老院居民。版权所有（C）2012 -美国医学主任协会，Inc.
Background and Aims: Sarcopenia has been indicated as a reliable marker of frailty and poor prognosis among the oldest individuals. At present, no data are available on sarcopenia in the nursing home population. The aim of the current study was to explore the relationship between sarcopenia and all-cause mortality in a population of elderly persons aged 70 years and older living in a nursing home in Italy.Methods: This study was conducted among all subjects (n = 122) aged 70 years and older who lived in the teaching nursing home of Catholic University of Rome between August 1, 2010, and September 30, 2010. According to the European Working Group on Sarcopenia in Older People (EWGSOP), sarcopenia was diagnosed in presence of low muscle mass plus either low muscle strength or low physical performance. The primary outcome measure was survival after 6 months.Results: Forty residents (32.8%) were indentified as affected by sarcopenia. This condition was more common in men (68%) than in women (21%). During the follow-up period, 26 (21.3%) patients died. After adjusting for age, gender, cerebrovascular diseases, osteoarthritis, chronic obstructive pulmonary disease, activity of daily living impairment, and body mass index, residents with sarcopenia were more likely to die compared with those without sarcopenia (adjusted hazard ratio 2.34; 95% confidence interval 1.04-5.24).Conclusions: The present study suggests that among subjects living in a nursing home, sarcopenia is highly prevalent and is associated with a significantly increased risk of all-cause death. The current findings support the possibility that sarcopenia has an independent effect on survival among nursing home residents. Copyright (C) 2012 - American Medical Directors Association, Inc.