Expression of the dopamine transporter in rat and bullfrog retinas
Expression of the dopamine transporter in rat and bullfrog retinas
复制标题
DOI：
10.1097/01.wnr.0000220138.06542.44
复制
发表时间：
2006-05-29
期刊：
影响因子：
1.7
通讯作者：
Yang, Xiong-Li
中科院分区：
文献类型：
--
作者：
Cheng, Zhe;Zhong, Yong-Mei;Yang, Xiong-Li
我们通过免疫组织化学检查了大鼠和牛蛙视网膜中多巴胺转运蛋白的表达。在这两个物种中，多巴胺转运蛋白在所有多巴胺能无长突细胞的体细胞和过程中强烈表达。相反，在胆碱能无长突细胞中没有观察到多巴胺转运蛋白的免疫反应性。在大鼠多巴胺能丛状细胞中，还在终止于外丛状层的上升过程中观察到多巴胺转运蛋白免疫反应性。此外，多巴胺转运蛋白的标记广泛出现在外丛状层和内丛状层中。多巴胺转运蛋白的这种表达谱表明，多巴胺不仅可以在突触中被吸收，而且还可以被多巴胺转运蛋白在突触外吸收，并广泛分布在两个丛状层中。
We examined the expression of the dopamine transporter in rat and bullfrog retinas by immunohistochemistry. In both species, the dopamine transporter was strongly expressed in somata and processes of all dopaminergic amacrine cells. In contrast, no immunoreactivity for dopamine transporter was observed in cholinergic amacrine cells. In rat dopaminergic interplexiform cells, dopamine transporter immunoreactivity was also observed on the ascending processes terminating in the outer plexiform layer. Furthermore, the labeling for dopamine transporter diffusely appeared in both outer and inner plexiform layers. This expression profile of the dopamine transporter suggests that dopamine may be taken up not only in the synapses but also extrasynaptically by dopamine transporter, diffusely distributed in both plexiform layers.