Midlife healthy-diet index and late-life dementia and Alzheimer's disease.
Midlife healthy-diet index and late-life dementia and Alzheimer's disease.
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DOI：
10.1159/000327518
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发表时间：
2011-01
影响因子：
2.3
通讯作者：
Kivipelto M
中科院分区：
文献类型：
--
作者：
Eskelinen MH;Ngandu T;Tuomilehto J;Soininen H;Kivipelto M
目的：研究饮食模式对痴呆和阿尔茨海默病（AD）的长期影响。在中年调查的基于人群的队列中随机选择的525名受试者中，共有385名（73%）受试者在14年后的CAIDE研究中重新检查。健康饮食指数（范围0-17），包括健康和不健康的饮食成分。与不健康饮食的人（0-8分）相比，健康饮食的人（健康饮食指数>8分）患痴呆症（OR 0.12，95% CI 0.02-0.85）和AD（OR 0.08，95% CI 0.01-0.89）的风险降低，调整了几个可能的混杂因素。中年健康饮食与晚年痴呆/AD风险降低相关。这些发现强调了饮食模式的重要性，并可能使痴呆/AD预防或推迟的更有效措施成为可能。
To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD). Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0–17) was constructed including both healthy and unhealthy dietary components. Persons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02–0.85) and AD (OR 0.08, 95% CI 0.01–0.89) compared with persons with an unhealthy diet (0–8 points), adjusting for several possible confounders. Healthy diet at midlife is associated with a decreased risk of dementia/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia/AD prevention or postponement possible.