Evidence of Henipavirus Infection in West African Fruit Bats
Evidence of Henipavirus Infection in West African Fruit Bats
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DOI：
10.1371/journal.pone.0002739
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发表时间：
2008-07-23
期刊：
影响因子：
3.7
通讯作者：
Cunningham, Andrew A.
中科院分区：
文献类型：
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作者：
Hayman, David T. S.;Suu-Ire, Richard;Cunningham, Andrew A.
亨尼帕病毒是源于果蝠的新兴RNA病毒，可引起人类致命的脑炎。对加纳果蝠（巨翅目）进行了亨尼帕病毒抗体检测。采用Luminex多路微球试验，在Eidolon helvum血清中检测到尼帕病毒（39%，95%可信区间：27-51%）和亨德拉病毒（22%，95%可信区间：11-33%）抗体。病毒中和试验进一步证实30%（7/23）的Luminex阳性血清样本呈血清阳性。我们的结果表明，亨尼帕病毒存在于西非。
Henipaviruses are emerging RNA viruses of fruit bat origin that can cause fatal encephalitis in man. Ghanaian fruit bats (megachiroptera) were tested for antibodies to henipaviruses. Using a Luminex multiplexed microsphere assay, antibodies were detected in sera of Eidolon helvum to both Nipah (39%, 95% confidence interval: 27-51%) and Hendra (22%, 95% CI: 11-33%) viruses. Virus neutralization tests further confirmed seropositivity for 30% (7/23) of Luminex positive serum samples. Our results indicate that henipavirus is present within West Africa.