Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus).
Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus).
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自愿活动和遗传选择对家鼠（Mus homeus）有氧能力的影响。
DOI：
10.1152/jappl.1998.84.1.69
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Sieck,GC
中科院分区：
文献类型：
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作者：
Swallow,JG;GarlandJr,T;Carter,PA;Zhan,WZ;Sieck,GC
Swallow，John G.，小西奥多加兰，帕特里克A. Carter，Wen-Zhi Zhan，and加里C. Sieck.自愿活动和遗传选择对家鼠有氧能力的影响（Mus marticicus）.J. Appl. Physiol.84（1）：69-76，1998.-开发了一种动物模型，以研究“自然”（10代遗传选择，用于在跑步轮上进行高自愿活动）和“养育”（7-8周接触或不接触跑步轮，从断奶开始）对运动生理学组分的影响。在实验结束时，来自两个轮访问组的小鼠的体重明显轻于来自久坐组的小鼠。在车轮进入组，一个统计学上显着的，负相关的活动和最终的体重之间存在。在测量的最大耗氧量在强迫跑台运动（V steco 2最大），车轮访问的小鼠比久坐不动的小鼠显着更合作，但是，试验质量是不是一个显着的预测V steco 2最大值的个体差异。巢式双因素协方差分析表明，遗传选择的历史和访问车轮V steco 2最大值有显着的积极影响。轮访问选择的小鼠之间存在12%的差异，具有最高的质量校正Vsteco 2 max，和久坐不动的对照小鼠，具有最低的Vsteco 2 max。在Vsteco 2 max时，轮入组的呼吸交换率也显著较低。我们的研究结果表明，自愿活动水平（行为）和有氧能力（生理）之间可能存在遗传相关性。
Swallow, John G., Theodore Garland, Jr., Patrick A. Carter, Wen-Zhi Zhan, and Gary C. Sieck.Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus).J. Appl. Physiol.84(1): 69–76, 1998.—An animal model was developed to study effects on components of exercise physiology of both “nature” (10 generations of genetic selection for high voluntary activity on running wheels) and “nurture” (7–8 wk of access or no access to running wheels, beginning at weaning). At the end of the experiment, mice from both wheel-access groups were significantly lighter in body mass than mice from sedentary groups. Within the wheel-access group, a statistically significant, negative relationship existed between activity and final body mass. In measurements of maximum oxygen consumption during forced treadmill exercise (V˙o2 max), mice with wheel access were significantly more cooperative than sedentary mice; however, trial quality was not a significant predictor of individual variation in V˙o2 max. Nested two-way analysis of covariance demonstrated that both genetic selection history and access to wheels had significant positive effects on V˙o2 max. A 12% difference inV˙o2 maxexisted between wheel-access selected mice, which had the highest mass-correctedV˙o2 max, and sedentary control mice, which had the lowest. The respiratory exchange ratio at V˙o2 maxwas also significantly lower in the wheel-access group. Our results suggest the existence of a possible genetic correlation between voluntary activity levels (behavior) and aerobic capacity (physiology).