Fused deposition modeling of novel scaffold architectures for tissue engineering applications
Fused deposition modeling of novel scaffold architectures for tissue engineering applications
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DOI：
10.1016/s0142-9612(01)00232-0
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发表时间：
2002-02-01
期刊：
影响因子：
14
通讯作者：
Teoh, SH
中科院分区：
文献类型：
--
作者：
Zein, I;Hutmacher, DW;Teoh, SH
熔融沉积成型技术是一种快速成型技术，用于制备具有蜂窝状图案、完全互连的通道网络、可控孔隙率和通道尺寸的新型支架。开发了一种生物可吸收聚合物聚（ε-己内酯）（PCL）作为长丝成型材料，以制备多孔支架。由一层层定向排列的微丝组成，使用计算机控制的挤压和沉积过程。PCL支架的通道尺寸范围为160-700 μ m，细丝直径为260-370 μ m，孔隙率为48- 77%，以及规则的几何蜂窝孔，这取决于加工参数。不同孔隙率的支架也表现出多孔固体在这种负载下的压缩应力-应变行为特征的模式。压缩刚度为4 ~ 77 MPa，屈服强度为0.4 ~ 3.6MPa，屈服应变为4%~ 28%。测量数据的分析显示支架孔隙率与基于幂律关系的压缩性能之间的高度相关性。(C)2001爱思唯尔科技有限公司版权所有。
Fused deposition modeling, a rapid prototyping technology, was used to produce novel scaffolds with honeycomb-like pattern, fully interconnected channel network, and controllable porosity and channel size. A bioresorbable polymer poly(epsilon -caprolactone) (PCL) was developed as a filament modeling material to produce porous scaffolds. made of layers of directionally aligned microfilaments, using this computer-controlled extrusion and deposition process. The PCL scaffolds were produced with a range of channel size 160-700 mum, filament diameter 260-370 mum and porosity 48-77%, and regular geometrical honeycomb pores, depending on the processing parameters. The scaffolds of different porosity also exhibited a pattern of compressive stress-strain behavior characteristic of porous solids under such loading. The compressive stiffness ranged from 4 to 77 MPa, yield strength from 0.4 to 3.6MPa and yield strain from 4% to 28%. Analysis of the measured data shows a high correlation between the scaffold porosity and the compressive properties based on a power-law relationship. (C) 2001 Elsevier Science Ltd. All rights reserved.