Metabolic Profiles of Obesity in American Indians: The Strong Heart Family Study.
Metabolic Profiles of Obesity in American Indians: The Strong Heart Family Study.
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DOI：
10.1371/journal.pone.0159548
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Zhao J
中科院分区：
文献类型：
--
作者：
Zhao Q;Zhu Y;Best LG;Umans JG;Uppal K;Tran VT;Jones DP;Lee ET;Howard BV;Zhao J
肥胖是一种典型的由能量摄入和消耗不平衡引起的代谢紊乱。美洲印第安人的肥胖和糖尿病发病率高得不成比例。本研究的目的是确定431名血糖正常的美国印第安人参与强心脏家庭研究的肥胖代谢谱。使用非靶向液相色谱-质谱法，我们检测到1364种不同的m/z特征与当前代谢组学数据库中的已知化合物相匹配。我们进行了多变量分析，以确定肥胖的代谢特征，并根据标准肥胖指标进行调整。在调整协变量和多重检验后，5种代谢物与体重指数相关，7种与腰围相关。其中，有三个与两者都有关联。与肥胖相关的代谢物大部分属于脂类，如脂肪酰胺、鞘脂、丙烯醇脂和类固醇衍生物。其他已确定的代谢物是氨基酸或多肽。在鉴定的9种代谢物中，有5种代谢物（油基乙醇酰胺、甘露糖酰二肌醇-磷酸化神经酰胺、磷酸、谷氨酸和犬尿氨酸）先前与肥胖或其相关途径有关。未来的研究有理由在更大的人群或其他种族群体中重复这些发现。
Obesity is a typical metabolic disorder resulting from the imbalance between energy intake and expenditure. American Indians suffer disproportionately high rates of obesity and diabetes. The goal of this study is to identify metabolic profiles of obesity in 431 normoglycemic American Indians participating in the Strong Heart Family Study. Using an untargeted liquid chromatography–mass spectrometry, we detected 1,364 distinct m/z features matched to known compounds in the current metabolomics databases. We conducted multivariate analysis to identify metabolic profiles for obesity, adjusting for standard obesity indicators. After adjusting for covariates and multiple testing, five metabolites were associated with body mass index and seven were associated with waist circumference. Of them, three were associated with both. Majority of the obesity-related metabolites belongs to lipids, e.g., fatty amides, sphingolipids, prenol lipids, and steroid derivatives. Other identified metabolites are amino acids or peptides. Of the nine identified metabolites, five metabolites (oleoylethanolamide, mannosyl-diinositol-phosphorylceramide, pristanic acid, glutamate, and kynurenine) have been previously implicated in obesity or its related pathways. Future studies are warranted to replicate these findings in larger populations or other ethnic groups.