Quaternary Ammonium Salt-Based Cross-Linked Micelles to Combat Biofilm
Quaternary Ammonium Salt-Based Cross-Linked Micelles to Combat Biofilm
复制标题
季铵盐基交联胶束对抗生物膜
DOI：
10.1021/acs.bioconjchem.9b00010
复制
发表时间：
2019-03-01
影响因子：
4.7
通讯作者：
Zhang, Shiyong
中科院分区：
文献类型：
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作者：
Liu, Fangqin;He, Dengfeng;Zhang, Shiyong
由于生物膜自身产生的胞外聚合物（EPS），很难被常用的抗菌剂根除。本文中，创建了一种新的基于季铵盐的交联胶束（QAS@CM）以对抗生物膜。QAS@CM首先通过多电荷相互作用吸附到生物膜表面，然后以纳米颗粒的形式渗透EPS并扩散到整个膜中。通过响应生物膜酸/脂肪酶微环境，这些纳米颗粒将进一步分解成季铵低聚物，并作为多价抑制剂有效地破坏已建立的生物膜并杀死其中相应的细菌。
Due to self-produced extracellular polymeric substances (EPS), biofilms are hard to eradicate by common antimicrobials. Herein, a new quaternary ammonium salt based cross-linked micelle (QAS@CM) was created to combat biofilms. The QAS@CM adsorbed first onto the biofilm surface through multicharged interaction, then penetrated the EPS in the form of nanoparticles and diffused throughout the films. By responding to the biofilm acid/lipase microenvironment, these nanoparticles would further break into quaternary ammonium oligomers and act as the polyvalent inhibitors to effectively destroy the established biofilm and kill the corresponding bacteria within it.