Salvianolic acid A as a multifunctional agent ameliorates doxorubicin-induced nephropathy in rats.
Salvianolic acid A as a multifunctional agent ameliorates doxorubicin-induced nephropathy in rats.
复制标题
Salvianolic A作为多功能剂A可以改善大鼠阿霉素诱导的肾病。
DOI：
10.1038/srep12273
复制
发表时间：
2015-07-21
影响因子：
4.6
通讯作者：
Che X
中科院分区：
文献类型：
--
作者：
Fan HY;Yang MY;Qi D;Zhang ZK;Zhu L;Shang-Guan XX;Liu K;Xu H;Che X
肾病综合征(NS)仍然是一个治疗挑战。到目前为止还没有理想的治疗方法。有证据表明，在改善肾损害方面，多药联合治疗比单一药物治疗效果更好。丹酚酸A(SAA)是丹参的主要活性成分。以往的研究表明，SAA是一种多靶点的药物，具有多种药理活性。SAA的多效性预示了其在治疗NS方面的潜力。本研究探讨了SAA对阿霉素肾病的影响。测定肾功能相关生化指标、血液流变学及氧化应激状态，并进行光镜、透射电子显微镜、免疫印迹等组织学检查。结果显示，SAA治疗可减轻组织学损害，缓解蛋白尿、低蛋白血症和高脂血症，减轻氧化应激，并改善血液流变学。此外，SAA还能恢复Podocin的表达，下调NF-κB p65和p-IκBα的表达，上调IκBα蛋白的表达。总体而言，作为一种多功能药物，SAA在阿霉素肾病中具有良好的肾脏保护作用。其抗炎、抗氧化、改善足细胞损伤、改善血液流变学和降血脂作用可能是其治疗作用的重要组成部分。这些都表明SAA可能是治疗NS的一种有前途的药物。
Nephrotic syndrome (NS) is still a therapeutic challenge. To date there is no ideal treatment. Evidence suggest that multidrug therapy has more effect than monotherapy in amelioration of renal injury. Salvianolic acid A (SAA) is the major active component of Salviae Miltiorrhizae Bunge. Previous studies have demonstrated that SAA is a multi-target agent and has various pharmacological activities. The pleiotropic properties of SAA predict its potential in the treatment of NS. The study investigated the effect of SAA on doxorubicin-induced nephropathy. The kidney function related-biochemical changes, hemorheological parameters and oxidative stress status were determined, and histological examination using light and transmission electron microcopies and western blot analysis were also performed. Results revealed that treatment with SAA alleviated histological damages, relieved proteinuria, hypoalbuminemia and hyperlipidemia, reduced oxidative stress, as well as improving hemorheology. Furthermore, SAA restored podocin expression, down-regulated the expression of NF-κB p65 and p-IκBα while up-regulating IκBα protein expression. Overall, as a multifunctional agent, SAA has a favorable renoprotection in doxorubicin-induced nephropathy. The anti-inflammation, antioxidant, amelioration of podocyte injury, improvement of hemorheology and hypolipidemic properties may constituent an important part of its therapeutic effects. All these indicate that SAA is likely to be a promising agent for NS.