ODORANT-SELECTIVE GENES AND NEURONS MEDIATE OLFACTION IN C-ELEGANS
ODORANT-SELECTIVE GENES AND NEURONS MEDIATE OLFACTION IN C-ELEGANS
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DOI：
10.1016/0092-8674(93)80053-h
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发表时间：
1993-08-13
期刊：
影响因子：
64.5
通讯作者：
HORVITZ, HR
中科院分区：
文献类型：
--
作者：
BARGMANN, CI;HARTWIEG, E;HORVITZ, HR
嗅觉是检测挥发性气味的一种通用且敏感的机制。结果表明，线虫C.秀丽线虫检测许多挥发性化学物质，这些化学物质可以是引诱剂、驱避剂或低浓度的引诱剂和高浓度的驱避剂。通过激光消融，我们已经确定了检测挥发性气味的化学感觉神经元。对挥发性气味物质的趋化作用与对水溶性引诱剂的趋化作用需要不同的感觉神经元，表明C。秀丽线虫可能有分别与嗅觉和味觉相对应的感觉。单个神经元具有复杂的感觉特性，因为只有两种类型的感觉神经元才能感觉到六种可区分的挥发性气味。对挥发性气味物的趋化性被odr基因的突变破坏，这可能与气味感觉或信号转导有关。
Olfaction is a versatile and sensitive mechanism for detecting volatile odorants. We show that the nematode C. elegans detects many volatile chemicals, which can be attractants, repellents, or attractants at low concentrations and repellents at high concentrations. Through laser ablation, we have identified chemosensory neurons that detect volatile odorants. Chemotaxis to volatile odorants requires different sensory neurons from chemotaxis to water-soluble attractants, indicating that C. elegans might have senses that correspond to smell and taste, respectively. Single neurons have complex sensory properties, since six distinguishable volatile odorants are sensed by only two types of sensory neurons. Chemotaxis to subsets of volatile odorants is disrupted by mutations in the odr genes, which might be involved in odorant sensation or signal transduction.