Impact of selenium on mood and quality of life: A randomized, controlled trial
Impact of selenium on mood and quality of life: A randomized, controlled trial
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DOI：
10.1016/j.biopsych.2005.06.019
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发表时间：
2006-01-15
影响因子：
10.6
通讯作者：
Bliss, J
中科院分区：
文献类型：
--
作者：
Rayman, M;Thompson, A;Bliss, J
背景：硒对大脑很重要。三个小的，已发表的研究表明，硒补充或剥夺对健康志愿者的情绪的影响。我们调查了这些发现在一个更大的scale.Methods：在这个双盲，安慰剂对照干预，501名年龄在60-74岁的英国参与者被随机分配到接受100，200或300亩硒/天作为高硒酵母或安慰剂酵母。心情（情绪状态特征-双相量表，[POMS-BI]问卷），“生活质量”（SF-36问卷）和血浆硒在基线和6个月时进行测量。结果：补充显著增加血浆硒高于基线值：从90（19）ng/g的总体平均值（SD）分别到安慰剂、100、200、300 μ g硒组的9.1（26）、144（27）、191（41）和227（53）ng/g（p <0.001）。448名参与者在两个时间点完成了POMS-BI问卷调查，两种剂量之间的总情绪或情绪子量表评分没有显着差异。补充6个月后，四个剂量的平均（SD）总情绪评分为163（36），161（37），162（33），162（34），F-3，F-443 = .25，p = .86。生活质量也同样不受影响。结论：没有证据表明，硒补充有益于情绪或生活质量在这些老年志愿者。虽然这与以前的一些结果不一致，但我们强大的研究设计，更大的样本量和更长的补充期，以及大脑是硒保留的特权场所的证据，表明Ibis是一个可靠的发现。
Background: Selenium is known to be important to the brain. Three small, published studies have suggested an effect of selenium supplementation or deprivation on mood in healthy volunteers. We investigated these findings on a much larger scale.Methods: In this double-blind, placebo-controlled intervention, 501 UK participants aged 60-74 were randomly allocated to receive 100, 200 or 300 mu g selenium/d as high-selenium yeast or placebo yeast. Mood (Profile of Moods States - Bipolar Form, [POMS-BI] questionnaire), "quality of life" (Short Form 36 [SF-36] questionnaire) and plasma selenium were measured at baseline and six months.Results: Supplementation significantly increased plasma selenium above baseline values: from an overall mean (SD) of 90(19) ng/g to 9.1(26), 144(27), 191(41) and 227(53) ng/g in the placebo, 100, 200, 300 mu g selenium groups respectively (p < .001). Four hundred forty-eight participants completed the POMS-BI questionnaires at both time points, with no significant differences in total mood or mood-subscale scores seen between doses. After six months of supplementation, mean (SD) total mood scores for the four doses were 163(36), 161(37), 162(33), 162(34), F-3,F-443 = .25, p = .86. Quality of life was similarly unaffected.Conclusions: There was no evidence that selenium supplementation benefited mood or quality of life in these elderly volunteers. Though Though this is at odds with some previous results, our robust study design, much larger sample size and longer supplementation period, together with the evidence that the brain is a privileged site for selenium retention, suggest that Ibis is a reliable finding.