Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function.
Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function.
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DOI：
10.1093/ajcn/71.6.1421
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发表时间：
2000-06
期刊：
影响因子：
--
通讯作者：
M. Rosenbaum;J. Hirsch;E. Murphy;R. Leibel
中科院分区：
文献类型：
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作者：
M. Rosenbaum;J. Hirsch;E. Murphy;R. Leibel
体重的增加和减轻分别增加和减少能量消耗，与代谢质量的变化不成比例。我们假设与体重增加或减轻相关的能量消耗的变化部分是由于儿茶酚胺释放、甲状腺激素、碳水化合物利用或其组合的变化。方法对肥胖和非肥胖受试者在正常体重、体重减轻或增加期间、稳定体重低于或高于正常体重10%-20%时的尿儿茶酚胺排泄量、血清甲状腺激素浓度和3小时口服葡萄糖耐量试验结果进行检测。结果尿去甲肾上腺素排泄量在体重下降时和体重增加时和体重增加后显著减少。在体重减轻期间和之后，反向三碘甲腺原氨酸的血清浓度显著增加，而在体重增加期间和之后，三碘甲腺原氨酸的血清浓度显著增加（约0%）。肥胖受试者体重增加后，口服葡萄糖耐量试验期间的血清胰岛素和葡萄糖浓度显著增加。尿去甲肾上腺素排泄的百分比变化和血清三碘甲腺原氨酸浓度的百分比变化与能量消耗的百分比变化以及彼此之间的百分比变化显著相关。结论：体重的变化与儿茶酚胺排泄和甲状腺激素的变化有关，这可能是由于对能量消耗的影响，有利于恢复正常体重。体重增加诱导肥胖者比从不肥胖者更明显的胰岛素抵抗，这表明全身脂肪对这种现象的阈值效应。
BACKGROUND Weight gain and loss increases and decreases energy expenditure, respectively, out of proportion to changes in metabolic mass. OBJECTIVE We hypothesized that changes in energy expenditure associated with weight gain or loss were due in part to changes in catecholamine release, thyroid hormones, carbohydrate utilization, or a combination thereof. METHODS Urinary catecholamine excretion, serum thyroid hormone concentrations, and results of 3-h oral-glucose-tolerance tests were examined in obese and never-obese subjects at their usual weights, during weight loss or gain, and at stable weights 10-20% below or 10% above usual. RESULTS Urinary norepinephrine excretion decreased significantly during and after weight loss and increased during and after weight gain. Serum concentrations of reverse triiodothyronine increased significantly during and after weight loss, whereas serum concentrations of triiodothyronine increased significantly (by approximately 0%) during and after weight gain. Serum insulin and glucose concentrations during the oral-glucose-tolerance test increased significantly after weight gain in obese subjects. The percentage change in urinary norepinephrine excretion and in serum concentrations of triiodothyronine were significantly correlated with percentage changes in energy expenditure and with each other. CONCLUSIONS Changes in body weight were associated with changes in catecholamine excretion and thyroid hormones, which might-by virtue of the effects on energy expenditure-have favored a return to usual body weight. Weight gain induced more apparent insulin resistance in the obese than the never-obese subjects, suggesting a threshold effect of total body fat on this phenomenon.