Genetics of human body size and shape: evidence for an oligogenic control of adiposity
Genetics of human body size and shape: evidence for an oligogenic control of adiposity
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DOI：
10.1080/030144699282994
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发表时间：
1999-01-01
影响因子：
1.7
通讯作者：
Kobyliansky, E
中科院分区：
文献类型：
--
作者：
Ginsburg, E;Livshits, G;Kobyliansky, E
在作者之前的一项研究中，在来自吉尔吉斯斯坦、土库曼斯坦和丘瓦希亚的每个家系样本中，发现了四个被认为由四个不重叠的基因亚群控制的主因子。通过22项皮褶、周长和指数的测量评估的肥胖总变异中，约有90%被这些因素覆盖。本研究提供了这四个因素中每一个因素的分离分析结果。通过通常的传递概率检验，所有12个分析都接受主基因(MG)控制-3个群体的4个性状。一些最节俭的MG模型包括非MG效应，例如配偶之间、父母和子女之间以及兄弟姐妹之间的残差相关性。柯尔克孜族样本显示出显著的分类交配效应，这是通过配偶中假定的MG基因型值之间的相关性来衡量的。可归因于MG效应的性状变异比例从0.296(丘瓦希亚样本中的因子F4)到0.596(吉尔吉斯斯坦样本中的相同因子)。假设在决定肥胖的遗传控制中可以识别四个独立的大效应基因，分别是个体积累皮下脂肪的倾向、躯干和四肢之间的分布、体内脂肪积累的倾向及其在上下半身之间的分配。在每个人群中，四个最简约的MG模型的统一形成了解释总肥胖率从0.364(楚瓦希亚)到0.540(吉尔吉斯斯坦)的寡头模型。
In a previous study by the authors in each of the pedigree samples from Kirghizstan, Turkmenia and Chuvashia, four principal factors supposedly controlled by four non-overlapping gene subsets were found. About 90% of total variation of adiposity as assessed by 22 measurements of skinfolds, circumferences and indices were covered by these factors. This study provides results of segregation analysis of each of these four factors. By the usual transmission probability tests, major gene (MG) control was accepted in all 12 analyses-four traits in three populations. Some of the most parsimonious MG models included non-MG effects, such as correlation of residuals between spouses, between parent and offspring and between sibs. The Kirghizian samples showed a significant assortative mating effect as measured by the correlation between genotypic values at putative MG in spouses. The proportion of the trait variance attributable to the MG effect varied from 0.296 (factor F4 in the Chuvashia sample) to 0.596 (the same factor in the Kirghizian sample). It is assumed that four independent large-effect genes can be recognized in the genetic control of adiposity determining, respectively, individual predisposition to accumulate subcutaneous fat, its distribution between the body trunk and extremities, predisposition to accumulate inner fat and its distribution between the upper and lower body parts. In each population, unification of the four most parsimonious MG models forms oligogenic models explaining from 0.364 (Chuvashia) to 0.540 (Kirghizstan) of total adiposity.