Molecular Mechanisms of Parthanatos and Its Role in Diverse Diseases.
Molecular Mechanisms of Parthanatos and Its Role in Diverse Diseases.
复制标题
Parthanatos的分子机制及其在多种疾病中的作用
DOI：
10.3390/ijms23137292
复制
发表时间：
2022-06-30
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
凋亡、程序性坏死和自噬的差异进化，parthanatos是由DNA损伤引起的聚（ADP-核糖）聚合酶1（PARP 1）介导的细胞死亡形式。PARP 1超活化刺激凋亡诱导因子（AIF）核转位，并加速烟酰胺腺嘌呤二核苷酸（NAD+）和三磷酸腺苷（ATP）消耗，导致DNA片段化。致死机制主要包括DNA损伤、PARP 1过度激活、PAR积累、NAD+和ATP耗竭以及AIF核转位。目前，据报道，parthanatos广泛存在于不同的疾病（肿瘤，视网膜疾病，神经系统疾病，糖尿病，肾脏疾病，心血管疾病，缺血-再灌注损伤.）。过量或有缺陷的parthanatos有助于病理性细胞损伤;因此，parthanatos在许多疾病的治疗和预防中至关重要。在这项工作中，parthanatos及其相关疾病的特点和分子机制进行了总结。最近的调查结果所提出的问题也提出。进一步了解parthanatos将为相关疾病提供新的治疗选择。
Differential evolution of apoptosis, programmed necrosis, and autophagy, parthanatos is a form of cell death mediated by poly(ADP-ribose) polymerase 1 (PARP1), which is caused by DNA damage. PARP1 hyper-activation stimulates apoptosis-inducing factor (AIF) nucleus translocation, and accelerates nicotinamide adenine dinucleotide (NAD+) and adenosine triphosphate (ATP) depletion, leading to DNA fragmentation. The mechanisms of parthanatos mainly include DNA damage, PARP1 hyper-activation, PAR accumulation, NAD+ and ATP depletion, and AIF nucleus translocation. Now, it is reported that parthanatos widely exists in different diseases (tumors, retinal diseases, neurological diseases, diabetes, renal diseases, cardiovascular diseases, ischemia-reperfusion injury...). Excessive or defective parthanatos contributes to pathological cell damage; therefore, parthanatos is critical in the therapy and prevention of many diseases. In this work, the hallmarks and molecular mechanisms of parthanatos and its related disorders are summarized. The questions raised by the recent findings are also presented. Further understanding of parthanatos will provide a new treatment option for associated conditions.
登录
查看更多内容
影响因子：
8.6
作者：
Calabresi, Paolo;Di Filippo, Massimiliano;Gallina, Antongiulio;Wang, Yingfei;Stankowski, Jeannette N.;Picconi, Barbara;Dawson, Valina L.;Dawson, Ted M.
通讯作者：
Dawson, Ted M.
DOI：
10.3324/haematol.2012.066399
发表时间：
2012-12-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Aurelius, Johan;Martner, Anna;Thoren, Fredrik B.
通讯作者：
Thoren, Fredrik B.
影响因子：
4
作者：
Ame, Jean-Christophe;Fouquerel, Elise;Schreiber, Valerie
通讯作者：
Schreiber, Valerie
DOI：
10.1073/pnas.0606526103
发表时间：
2006-11-28
影响因子：
11.1
作者：
Andrabi, Shaida A.;Kim, No Soo;Dawson, Ted M.
通讯作者：
Dawson, Ted M.
影响因子：
20.3
作者：
Aurelius, Johan;Thoren, Fredrik B.;Martner, Anna
通讯作者：
Martner, Anna