Recent Developments in Understanding the Role of Aqueous Humor Outflow in Normal and Primary Open Angle Glaucoma.
Recent Developments in Understanding the Role of Aqueous Humor Outflow in Normal and Primary Open Angle Glaucoma.
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DOI：
10.1007/s40135-015-0072-x
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发表时间：
2015-06-01
影响因子：
0.9
通讯作者：
Fautsch MP
中科院分区：
文献类型：
--
作者：
Hann CR;Fautsch MP
原发性开角型青光眼（POAG）是世界上迅速老龄化的人口中的第二大致盲原因。POAG的特征在于后段神经结构的进行性变性，通常伴随眼内压升高。IOP的变化被认为是由房水正常流出的中断引起的。本文就近年来有关正常人和原发性开角型青光眼房水流出的研究作一综述。新的发现阐明生化和病理变化的影响POAG的眼组织。干细胞研究、淋巴标记物的鉴定以及小鼠模型的使用增加为研究人员提供了令人兴奋的新工具，以了解眼房水流出、与POAG相关的变化以及确定疾病的根本原因。
Primary open angle glaucoma (POAG) is the second leading cause of blindness in the world's rapidly aging population. POAG is characterized by progressive degeneration of neural structures in the posterior segment, often associated with a concomitant elevation of intraocular pressure. Changes in IOP are believed to be caused by a disruption in the normal outflow of aqueous humor. This article reviews recent research associated with normal and POAG aqueous humor outflow. Novel findings elucidating biochemical and pathological changes in the ocular tissues affected in POAG are presented. Stem cell research, identification of lymphatic markers, and increased use of mouse models give researchers exciting new tools to understand aqueous humor outflow, changes associated with POAG and identify underlying causes of the disease.